Joseph Y Lucisano

US Patent:

6472122, Oct 29, 2002

Filed:

Sep 9, 1999

Appl. No.:

09/393438

Inventors:

Joseph H. Schulman - Santa Clarita CA
Joseph Y. Lucisano - San Diego CA
Rajiv Shah - Rancho Palos Verdes CA
Charles L. Byers - Canyon Country CA
Shaun M. Pendo - Santa Maria CA

Assignee:

Medtronic Minimed, Inc. - Northridge CA

International Classification:

G03F 716

US Classification:

430311, 430315, 20419211, 20419215, 606 41, 427 21, 427 212, 427 224, 427435, 427437

Abstract:

A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e. g. , 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80Â C. over a three month period.

US Patent:

6844023, Jan 18, 2005

Filed:

Sep 20, 2002

Appl. No.:

10/251633

Inventors:

Joseph H. Schulman - Santa Clarita CA, US
Joseph Y. Lucisano - San Diego CA, US
Rajiv Shah - Rancho Palos Verdes CA, US
Charles L. Byers - Canyon Country CA, US
Shaun M. Pendo - Santa Maria CA, US

Assignee:

Medtronic Minimed, Inc. - Norhtridge CA

International Classification:

B05D 300

US Classification:

427 224, 427 21, 427 212, 607 2, 607116, 156 8916, 20429804, 257698, 257702, 174 505

Abstract:

A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e. g. , 5-10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80 C. over a three month period.

US Patent:

7160672, Jan 9, 2007

Filed:

Jun 10, 2005

Appl. No.:

11/150547

Inventors:

Joseph H. Schulman - Santa Clarita CA, US
Joseph Y. Lucisano - San Diego CA, US
Rajiv Shah - Rancho Palos Verdes CA, US
Charles L. Byers - Canyon County CA, US
Shaun M. Pendo - Santa Maria CA, US

Assignee:

Alfred E. Mann Foundation for Scientific Research - Sylmar CA

International Classification:

G03C 5/00
C23C 14/00

US Classification:

430315, 430311, 2041921, 20419215

Abstract:

A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zerconia, or other ceramic, less than 25 microns thick, e. g. , 5–10 microns thick. The alumina layer(s) may be applied at relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80 C. over a three month period.

US Patent:

7235350, Jun 26, 2007

Filed:

Oct 20, 2004

Appl. No.:

10/969758

Inventors:

Joseph H. Schulman - Santa Clarita CA, US
Joseph Y. Lucisano - San Diego CA, US
Rajiv Shah - Rancho Palos Verdes CA, US
Charles L. Byers - Canyon Country CA, US
Shaun M. Pendo - Santa Maria CA, US

Assignee:

Alfred E. Mann Foundation - Sylmar CA

International Classification:

B32B 3/00
B32B 18/00

US Classification:

430315, 20419211, 428209, 428210, 428469, 428701

Abstract:

A protective, biocompatible coating or encapsulation material protects and insulates a component or device intended to be implanted in living tissue. The coating or encapsulation material comprises a thin layer or layers of alumina, zirconia or other ceramic, less than 25 microns thick, e. g. , 5-10 microns thick. The alumina layer(s) may be applied at a relatively low temperature. Once applied, the layer provides excellent hermeticity, and prevents electrical leakage. Even though very thin, the alumina layer retains excellent insulating characteristics. In one embodiment, an alumina layer less than about 6 microns thick provides an insulative coating that exhibits less than 10 pA of leakage current over an area 75 mils by 25 mils area while soaking in a saline solution at temperatures up to 80 C. over a three month period.

US Patent:

7248912, Jul 24, 2007

Filed:

Oct 31, 2003

Appl. No.:

10/698911

Inventors:

David A. Gough - Cardiff CA, US
Michael C. Jablecki - La Jolla CA, US
Joseph Y. Lucisano - San Diego CA, US
Mark B. Catlin - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 5/00

US Classification:

600347, 600316, 600345

Abstract:

A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes a multiplicity of detectors, constructed and arranged to improve the probability that one or more detectors will have access to a vascular source at points in time sufficient to permit accurate measurements to be taken. Means and methods for calculating solute levels using the sensor device of the invention are also provided.

US Patent:

7336984, Feb 26, 2008

Filed:

Nov 20, 2003

Appl. No.:

10/719541

Inventors:

David A. Gough - Cardiff CA, US
Joseph Y. Lucisano - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 5/05
A61B 5/00

US Classification:

600345, 600347, 600365

Abstract:

The invention is the design of a biological measuring device for the determination of the concentration of biomolecules (e. g. glucose) in an environment which is designed for implantation into an individual or for use in the context of an external apparatus. The device contains a composite membrane that is essentially entirely permeable to oxygen and permeable to larger biomolecules only in discrete hydrophilic regions. The membrane diffusionally limits the access of biomolecules to an enzyme, present in the hydrophilic region that catalyzes the oxidation of the biomolecule to produce hydrogen peroxide. A sensor in communication with the hydrophilic region is used to determine the amount of product produced or the amount of excess oxygen present allowing for the concentration of the biomolecule to be determined.

US Patent:

7871456, Jan 18, 2011

Filed:

Aug 10, 2006

Appl. No.:

11/503461

Inventors:

David A. Gough - Solana Beach CA, US
Joseph Y. Lucisano - San Diego CA, US
Joe T. Lin - San Diego CA, US
Hwai-Min Tsay - San Diego CA, US
Drahoslav Lim - San Diego CA, US
Jana Limova, legal representative - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

B01D 53/22
B01D 71/06
A61B 5/00

US Classification:

95 45, 95 46, 95 51, 96 4, 96 11, 96 12, 96 13, 96 14, 210640, 21050027, 21050033, 600347, 600365, 20440305, 20440306, 204418

Abstract:

A membrane for use in an implantable glucose sensor including at least one crosslinked substantially hydrophobic polymer and at least one crosslinked substantially hydrophilic polymer; wherein the first and second polymers are different polymers and substantially form an interpenetrating polymer network, semi-interpenetrating polymer network, polymer blend, or copolymer. The membranes are generally characterized by providing a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). Three methods of making membranes from hydrophobic and hydrophilic monomers formed into polymer networks are provided, wherein according to at least two of the methods, the monomers may be substantially immiscible with one another.

US Patent:

7894870, Feb 22, 2011

Filed:

Aug 23, 2004

Appl. No.:

10/925074

Inventors:

Joseph Y. Lucisano - San Diego CA, US
Mark B. Catlin - San Diego CA, US

Assignee:

Glysens, Incorporated - San Diego CA

International Classification:

A61B 5/00

US Classification:

600345, 600347

Abstract:

At least one conductor is formed at a preselected location on a substrate made of a first insulating material having a high temperature resistance. The conductor is made from a solidified electrically conductive thick film material. A coating made of a second insulating material is formed over the substrate to hermetically seal at least a portion of the conductor. An exposed distal region of the conductor provides a detection electrode. The conductor has a reduced porosity that inhibits migration of fluid or constituents thereof through the conductor.