Joseph S Pastore

US Patent:

8513007, Aug 20, 2013

Filed:

Jul 24, 2012

Appl. No.:

13/556639

Inventors:

Marc S. Penn - Beachwood OH, US
Rahul Aras - Broadview Heights OH, US
Joseph Pastore - Mentor OH, US
Timothy J. Miller - Cleveland Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH
Juventas Therapeutics, Inc. - Cleveland OH

International Classification:

A61K 48/00
C12N 15/00

US Classification:

4353201, 514 44 R

Abstract:

A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

US Patent:

8513213, Aug 20, 2013

Filed:

Jul 24, 2012

Appl. No.:

13/556595

Inventors:

Marc S. Penn - Beachwood OH, US
Rahul Aras - Broadview Heights OH, US
Joseph Pastore - Mentor OH, US
Timothy J. Miller - Cleveland Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH
Juventas Therapeutics, Inc. - Cleveland OH

International Classification:

A61K 48/00
C12N 15/00

US Classification:

514 44R, 4353201

Abstract:

A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

US Patent:

20100272679, Oct 28, 2010

Filed:

Dec 15, 2008

Appl. No.:

12/808056

Inventors:

Marc S. Penn - Beachwood OH, US
Matthew Kiedrowski - Cleveland OH, US
Rahul Aras - Broadview Heights OH, US
Joseph Pastore - Concord OH, US

International Classification:

A61K 38/20
A61K 38/00
A61P 17/02

US Classification:

424 852, 514 11

Abstract:

A method of treating a wound in a subject includes administering directly to the wound or an area proximate the wound an amount of SDF-I effective to promote healing of the wound of the subject.

US Patent:

20120283315, Nov 8, 2012

Filed:

Aug 30, 2010

Appl. No.:

13/393141

Inventors:

Marc S. Penn - Beachwood OH, US
Rahul Aras - Braodview Heights OH, US
Joseph Pastore - Mentor OH, US
Timothy R. Miller - Cleveland Heights OH, US

International Classification:

A61K 31/711
A61P 9/10

US Classification:

514 44 R

Abstract:

A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

US Patent:

20130034523, Feb 7, 2013

Filed:

Oct 12, 2012

Appl. No.:

13/650726

Inventors:

The Cleveland Clinic Foundation - Cleveland OH, US
Juventas Therapeutics, Inc. - Cleveland OH, US
Matthew Kiedrowski - Cleveland OH, US
Joseph Pastore - Mentor OH, US

Assignee:

JUVENTAS THERAPEUTICS, INC. - Cleveland OH
THE CLEVELAND CLINIC FOUNDATION - Cleveland OH

International Classification:

A61K 38/19
A61P 17/02
A61K 48/00

US Classification:

424 932, 514 186, 514 44 R

Abstract:

The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of SDF-1 in, or proximate to, the wound. As described herein SDF-1 protein or an SDF-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of SDF-1 protein or an SDF-1 expression vector.

US Patent:

20130303597, Nov 14, 2013

Filed:

Jun 7, 2013

Appl. No.:

13/912435

Inventors:

Marc S. Penn - Beachwood OH, US
Rahul Aras - Broadview Heights OH, US
Joseph Pastore - Mentor OH, US
Timothy J. Miller - Cleveland Heights OH, US

International Classification:

A61K 48/00

US Classification:

514 44 R

Abstract:

Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.

US Patent:

20170049856, Feb 23, 2017

Filed:

Apr 28, 2015

Appl. No.:

15/305369

Inventors:

Marc S. PENN - Beachwood OH, US
Joseph PASTORE - Mentor OH, US
Timothy J. MILLER - Cleveland Heights OH, US
- Clevland OH, US

Assignee:

Juventas Therapeutics, Inc. - Cleveland OH
The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61K 38/19
A61K 48/00
A61K 9/00

Abstract:

Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Methods of treating subjects with advanced ischemic cardiomyopathy are further disclosed herein.

US Patent:

20140186419, Jul 3, 2014

Filed:

Feb 7, 2014

Appl. No.:

14/175319

Inventors:

- Cleveland OH, US
Rahul Aras - Broadview Heights OH, US
Joseph Pastore - Mentor OH, US

Assignee:

Juventas Therapeutics, Inc. - Cleveland OH
The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61K 38/19

US Classification:

424426, 514 44 R, 424400, 424445

Abstract:

The subject matter provided herein relates to method for inhibiting or mitigating scar formation in a wound of the skin, by increasing the concentration of SDF-1 in, or proximate to, the wound. As described herein SDF-1 protein or an SDF-1 expression vector can be administered to a wound or the area proximate a wound by providing a therapeutically effective amount of SDF-1 protein or an SDF-1 expression vector.