Joseph James Pero

US Patent:

20130210768, Aug 15, 2013

Filed:

Jun 6, 2011

Appl. No.:

13/701039

Inventors:

Kenneth L. Arrington - Revere MA, US
Vadim Dudkin - Lansdale PA, US
Mark E. Layton - Harleysville PA, US
Joseph E. Pero - Harleysville PA, US
Alexander J. Reif - Holland PA, US

International Classification:

C07D 471/04
C07F 7/10
C07D 519/00

US Classification:

514 63, 546118, 514303, 544362, 51425304, 544349, 514249, 544 582, 5142285, 546116, 514302, 544350, 544127, 5142342, 540575, 514218, 540492, 540544, 51421115, 546114, 514301, 51421021, 546 14, 546 16, 514278

Abstract:

The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.