Joseph J Pero

US Patent:

20130143880, Jun 6, 2013

Filed:

Aug 5, 2011

Appl. No.:

13/814870

Inventors:

Vadim Y. Dudkin - Lansdale PA, US
Mark E. Fraley - North Wales PA, US
Kenneth L. Arrington - Revere MA, US
Mark E. Layton - Harleysville PA, US
Alexander J. Reif - Holland PA, US
Kevin J. Rodzinak - Schwenksville PA, US
Joseph E. Pero - Harleysville PA, US

International Classification:

A61K 31/4745
C07D 235/26
A61K 31/4439
C07D 417/14
C07D 405/06
C07D 401/10
C07D 401/14
C07D 403/10
C07D 413/10
C07D 409/10
C07D 405/10
A61K 31/4184
C07D 413/02
C07D 401/02
C07D 403/02
A61K 31/4709
C07D 471/04

US Classification:

5142345, 5483064, 514387, 548247, 514378, 5462737, 514338, 546173, 514314, 544139, 546121, 514300, 544131, 544333, 514256, 544310, 514274, 544316, 546199, 514322

Abstract:

The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluRreceptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluRreceptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.

US Patent:

20210299113, Sep 30, 2021

Filed:

Sep 20, 2017

Appl. No.:

16/334400

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Peng LI - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US

International Classification:

A61K 31/4439
A61K 45/06
C07D 401/12
C07D 207/48
A61K 31/40
C07D 417/12
A61K 31/427
C07D 403/12
A61K 31/506
C07D 498/10
A61K 31/5386

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

US Patent:

20210253528, Aug 19, 2021

Filed:

Jul 8, 2019

Appl. No.:

16/973587

Inventors:

- Brentford, Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Israil PENDRAK - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US

International Classification:

C07D 213/64
C07C 271/28
C07C 275/30
C07C 235/20
C07D 207/273
A61K 45/06
A61K 31/506

Abstract:

The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X):

US Patent:

20200261411, Aug 20, 2020

Filed:

Feb 21, 2020

Appl. No.:

16/796989

Inventors:

- Brentford, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Guosen YE - Collegeville PA, US
Linda S. BARTON - Collegeville PA, US
Brian W. BUDZIK - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Jaclyn R. PATTERSON - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Robert SANCHEZ - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US
James V. THOMAS - Collegeville PA, US

International Classification:

A61K 31/40
C07F 7/08
C07D 513/04
C07D 491/107
C07D 417/12
C07D 409/12
A61K 45/06
A61K 31/695
A61K 31/5386
A61K 31/506
A61K 31/501
A61K 31/4439
A61K 31/429
A61K 31/427
A61K 31/4245
A61K 31/424
A61K 31/4155
A61K 31/407
A61K 31/4025
A61K 9/48
A61K 9/20
A61K 9/00
C07D 498/10
C07D 207/48
C07D 413/12
C07D 401/12
C07D 403/12

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

US Patent:

20200071310, Mar 5, 2020

Filed:

Dec 11, 2017

Appl. No.:

16/467148

Inventors:

- Brentford, Middlesex, GB
- Cambridge, Cambridgeshire, GB
Joseph E. PERO - King of Prussia PA, US
Charlotte Mary GRIFFITHS-JONES - Cambridge, Cambridgeshire, GB
Thomas Daniel HEIGHTMAN - Cambridge, Cambridgeshire, GB
David NORTON - Cambridge, Cambridgeshire, GB
Hendrika Maria Gerarda WILLEMS - Cambridge, Cambridgeshire, GB
Alison Jo-Anne WOOLFORD - Cambridge, Cambridgeshire, GB

International Classification:

C07D 413/08
C07D 413/14
C07D 403/08
C07D 401/14
C07D 417/14
C07D 419/14
A61P 11/00

Abstract:

The present invention relates to N-aryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formula (I):

US Patent:

20200055863, Feb 20, 2020

Filed:

Jul 29, 2019

Appl. No.:

16/524238

Inventors:

- Brentford, GB
Xiaomin Zhang - Shanghai, CN
Jian Wang - Shanghai, CN
Matthew Robert Sender - Collegeville PA, US
Eric Steven Manas - Collegeville PA, US
Raphael Anthony Rivero - Collegeville PA, US
Joseph E. Pero - Collegeville PA, US
Christopher Ernst Neipp - Collegeville PA, US
Vipulkumar Kantibhai Patel - Stevenage, GB

International Classification:

C07D 487/14
C07D 513/14
C07D 498/14
C07D 487/04
C07D 471/20
C07D 471/14
C07D 491/20

Abstract:

The present invention relates to novel compounds that inhibit Lp-PLAactivity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA, for example Alzheimer's disease.

US Patent:

20200031820, Jan 30, 2020

Filed:

Dec 11, 2017

Appl. No.:

16/467096

Inventors:

- Brentford, Middlesex, GB
- Cambride, Cambridgeshire, GB
Joseph E. PERO - King of Prussia PA, US
Charl mARY GRIFFITHS-JONES - King of Prussia PA, US
Thomas Daniel HEIGHTMAN - King of Prussia PA, US
Dvid NORTON - King of Prussia PA, US
Hendrika Maria WILLEMS - King of Prussia PA, US
Alison Jo-Anne WOOLFORD - King of Prussia PA, US

International Classification:

C07D 417/14
C07D 417/10
C07D 413/14
C07D 403/14
C07D 403/08
C07D 401/14

Abstract:

The present invention relates to 3-carboxylic acid pyrrole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of this invention include a compound of Formula (I):

US Patent:

20190216774, Jul 18, 2019

Filed:

Sep 20, 2017

Appl. No.:

16/334391

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Guosen YE - Collegeville PA, US
Lisa S. BARTON - Collegeville PA, US
Brian W. BUDZIK - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Jacyln R. PATTERSON - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Robert SANCHEZ - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US
James V. THOMAS - Collegeville PA, US

International Classification:

A61K 31/40
A61K 9/00
A61K 45/06
C07D 207/48
C07D 413/12
A61K 31/4245
A61K 31/506
C07D 403/12
C07D 409/12
C07D 417/12
A61K 31/4025
A61K 31/427
A61K 31/4155
A61K 31/429
C07D 513/04
C07D 401/12
A61K 31/4439
A61K 31/501
A61K 31/407
C07D 491/107
C07F 7/08
A61K 31/695
A61K 31/5386
C07D 498/10
A61K 31/424
A61K 9/48
A61K 9/20

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.