Joshua Matthew Parker

US Patent:

20170216479, Aug 3, 2017

Filed:

Jan 30, 2017

Appl. No.:

15/420016

Inventors:

- College Park MD, US
John T. Fourkas - Bethesda MD, US
Meghan Driscoll - Berwyn Heights MD, US
Floyd Bates, II - Upper Marlboro MD, US
Xiaoyu Sun - Laurel MD, US
Can Guven - Hilsboro OR, US
Joshua Parker - Washington DC, US

Assignee:

University of Maryland, College Park - College Park MD

International Classification:

A61L 15/42
A61L 15/58
A61L 27/50

Abstract:

The invention provides method of guiding unidirectional movement of a cell comprising exposing the cell to a surface comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements for a time period sufficient to bias actin polymerization within the cell. The invention also provides methods of inducing directional movement of a cell, and methods of harnessing an actin wave within a cell. In addition, the invention provides compositions comprising a contact side, wherein at least a portion of the contact side comprises a cell contact portion comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements, and methods of inducing healing of a wound of a subject comprising contacting the wound with the composition.