- Thousand Oaks CA, US Gunasekaran KANNAN - Newbury Park CA, US Li LI - Sammamish WA, US Joshua T. PEARSON - Seattle WA, US Margaret KAROW - Santa Rosa Valley CA, US
Assignee:
Amgen Inc. - Thousand Oaks CA
International Classification:
C07K 14/55 C07K 16/00
US Classification:
530351, 5303873, 435 696
Abstract:
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
Interleukin-2 Muteins For The Expansion Of T-Regulatory Cells
- Thousand Oaks CA, US Gunasekaran KANNAN - Newbury Park CA, US Li LI - Sammamish WA, US Joshua T. PEARSON - Seattle WA, US Margaret KAROW - Santa Rosa Valley CA, US
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
Womens Healthcare Of WesternWomens Healthcare Of Western Colorado 2525 N 8 St STE 202, Grand Junction, CO 81501 9702451168 (phone), 9702424299 (fax)
Education:
Medical School Des Moines University College of Osteopathic Medicine Graduated: 2001
Procedures:
Vaginal Repair Amniocentesis Cesarean Section (C-Section) Cystoscopy D & C Dilation and Curettage Delivery After Previous Caesarean Section Hysterectomy Myomectomy Osteopathic Manipulative Treatment Ovarian Surgery Skin Tags Removal Tubal Surgery Urinary Flow Tests Vaccine Administration Vaginal Delivery
Conditions:
Conditions of Pregnancy and Delivery Endometriosis Spontaneous Abortion Uterine Leiomyoma Abdominal Hernia
Languages:
English Spanish
Description:
Dr. Pearson graduated from the Des Moines University College of Osteopathic Medicine in 2001. He works in Grand Junction, CO and specializes in Obstetrics & Gynecology. Dr. Pearson is affiliated with Community Hospital and St Marys Hospital & Medical Center.
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Longwood University 2002 - 2006
BS, Business Administration