Joshua David Pearson

US Patent:

20210094997, Apr 1, 2021

Filed:

Oct 5, 2020

Appl. No.:

17/063566

Inventors:

- Thousand Oaks CA, US
Gunasekaran KANNAN - Daly City CA, US
Li LI - San Bruno CA, US
Joshua Thomas PEARSON - San Francisco CA, US
Margaret KAROW - Santa Rosa Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 14/55
C07K 16/00

Abstract:

Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

US Patent:

20180319859, Nov 8, 2018

Filed:

Feb 21, 2018

Appl. No.:

15/901705

Inventors:

- Thousand Oaks CA, US
Gunasekaran KANNAN - Daly City CA, US
Li LI - San Bruno CA, US
Joshua T. PEARSON - San Francisco CA, US
Margaret KAROW - Santa Rosa Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 14/55
C07K 16/00
A61K 38/00

Abstract:

Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

US Patent:

20170137485, May 18, 2017

Filed:

Jan 17, 2017

Appl. No.:

15/408281

Inventors:

- Thousand Oaks CA, US
Gunasekaran KANNAN - Daly City CA, US
Li LI - San Bruno CA, US
Joshua T. PEARSON - San Francisco CA, US
Margaret KAROW - Santa Rosa Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 14/55

Abstract:

Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

US Patent:

20170114291, Apr 27, 2017

Filed:

Jan 4, 2017

Appl. No.:

15/398394

Inventors:

- Westminster CO, US
Joshua B. Pearson - Lakewood CO, US
Harold A. Wright - Longmont CO, US

International Classification:

C10J 3/46
C01B 3/02
C10G 2/00

Abstract:

A mixing apparatus for producing a feedstock for a reformer, the mixing apparatus including at least one mixing vessel comprising a cylindrical vessel with a conical bottom; a steam inlet configured for introducing steam into the conical bottom; a carbonaceous material inlet configured for introducing a carbonaceous feed into the cylindrical vessel; and an outlet for a reformer feedstock comprising at least 0.3 pounds of steam per pound of carbonaceous material, with the at least one mixing vessel configured for operation at a pressure of greater than about 10 psig.

US Patent:

20150291897, Oct 15, 2015

Filed:

Jun 24, 2015

Appl. No.:

14/748964

Inventors:

- Westminster CO, US
Joshua B. Pearson - Lakewood CO, US
Harold A. Wright - Longmont CO, US

International Classification:

C10J 3/48
B01J 19/24
C01B 3/34
C10G 2/00

Abstract:

A system for the production of synthesis gas, the system including a mixing apparatus configured for combining steam with at least one carbonaceous material to produce a reformer feedstock; and a reformer comprising a cylindrical vessel containing a plurality of coiled tubes, each of the plurality of coiled tubes having a vertical height in the range of from about 40 feet 12.2 m) to about 100 feet (30.5 m) and a coil length that is at least four times the vertical height; at least one burner configured to combust a fuel and provide heat to maintain the reformer at a reformer temperature; at least one outlet for reformer product comprising synthesis gas; and at least one outlet for flue gas produced via combustion of fuel in the burners. A suitable mixing apparatus is also provided.

US Patent:

20150086432, Mar 26, 2015

Filed:

Dec 2, 2014

Appl. No.:

14/557972

Inventors:

- Commerce City CO, US
Joshua B. Pearson - Lakewood CO, US
Harold A. Wright - Longmont CO, US

International Classification:

C10G 2/00
C10J 3/80
C10J 3/32

US Classification:

422162

Abstract:

A system including a mixing apparatus configured to produce a reformer feedstock and comprising one or more cylindrical vessel having a conical bottom section, an inlet for superheated steam within the conical bottom section and an inlet for at least one carbonaceous material at or near the top of the cylindrical vessel, wherein the one or more cylindrical vessel is a pressure vessel configured for operation at a pressure in the range of from about 5 psig (34.5 kPa) to about 50 psig (344.7 kPa); a reformer configured to produce, from the reformer feedstock, a reformer product comprising synthesis gas, and also producing a hot flue gas; a synthesis gas conversion apparatus configured to catalytically convert at least a portion of the synthesis gas in the reformer product into synthesis gas conversion product, and to separate, from the synthesis gas conversion product, a spent catalyst stream and a tailgas.

US Patent:

20140261112, Sep 18, 2014

Filed:

May 28, 2014

Appl. No.:

14/289258

Inventors:

- Los Angeles CA, US
Joshua B. Pearson - Lakewood CO, US
Harold A. Wright - Longmont CO, US

Assignee:

RENTECH, INC. - Los Angeles CA

International Classification:

C10J 3/30
F23G 5/44
C10J 3/80
F23G 5/033
F23G 5/04

US Classification:

110222, 110244, 110224

Abstract:

A mixing apparatus for producing a feedstock for a reformer, the mixing apparatus including at least one mixing vessel comprising a cylindrical vessel with a conical bottom; a steam inlet configured for introducing steam into the conical bottom; a carbonaceous material inlet configured for introducing a carbonaceous feed into the cylindrical vessel; and an outlet for a reformer feedstock comprising at least 0.3 pounds of steam per pound of carbonaceous material, with the at least one mixing vessel configured for operation at a pressure of greater than about 10 psig.