Joshua S Tullis

US Patent:

6787555, Sep 7, 2004

Filed:

Apr 24, 2002

Appl. No.:

10/132981

Inventors:

Joshua Spector Tullis - Broomfield CO
John Charles Van Rens - Cincinnati OH
Michael Philip Clark - Loveland OH
Benjamin Eric Blass - Cincinnati OH
Michael George Natchus - Alpharetta GA
Biswanath De - Cincinnati OH

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

A61K 31506

US Classification:

514275, 544316, 544328, 544331

Abstract:

The present invention relates to 4-aryl triazoles having the formula: wherein R is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR , SR , S(O)R , S(O) R , and NR R ; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.

US Patent:

6790846, Sep 14, 2004

Filed:

May 7, 2002

Appl. No.:

10/140541

Inventors:

Michael Philip Clark - Loveland OH
Jane Far-Jine Djung - Mason OH
Steven Karl Laughlin - Taylor Mill KY
Joshua Spector Tullis - Broomfield CO
Michael George Natchus - Alpharetta GA
Biswanath De - Cincinnati OH

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

C07D41304

US Classification:

5142315, 51425404, 514269, 514326, 514340, 5462721, 546209, 544111, 544367, 544315

Abstract:

Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohns disease, ulcerative colitis, congestive heart, hypertension, chronic obstructive pulmonary disease, septic shock syndrome, tuberculosis, adult respiratory distress, asthma, atherosclerosis, muscle degeneration, periodontal disease, cachexia, Reiters syndrome, gout, acute synovitis, anorexia and bulimia nervosa fever, malaise, myalgia and headaches.

US Patent:

6919346, Jul 19, 2005

Filed:

Dec 2, 2003

Appl. No.:

10/726111

Inventors:

Michael Philip Clark - Loveland OH, US
Jane Far-Jine Djung - Mason OH, US
Steven Karl Laughlin - Taylor Mill KY, US
Joshua Spector Tullis - Broomfield CO, US
Michael George Natchus - Alpharetta GA, US
Biswanath De - Cincinnati OH, US

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

C07D413/04
A61K031/506
A61P009/04
A61P019/02

US Classification:

514256, 514269, 544315, 544317

Abstract:

Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohn's disease, ulcerative colitis, congestive heart, hypertension, chronic obstructive pulmonary disease, septic shock syndrome, tuberculosis, adult respiratory distress, asthma, atherosclerosis, muscle degeneration, periodontal disease, cachexia, Reiter's syndrome, gout, acute synovitis, anorexia and bulimia nervosa fever, malaise, myalgia and headaches.

US Patent:

20030013712, Jan 16, 2003

Filed:

Apr 24, 2002

Appl. No.:

10/133044

Inventors:

Joshua Tullis - Broomfield CO, US
John Rens - Cincinnati OH, US
Michael Clark - Loveland OH, US
Benjamin Blass - Cincinnati OH, US
Michael Natchus - Alpharetta GA, US
Biswanath De - Cincinnati OH, US

International Classification:

A61K031/53
A61K031/506
A61K031/4439
C07D417/02
C07D413/02
C 07D 4 3/02

US Classification:

514/241000, 514/275000, 514/340000, 514/359000, 544/212000, 544/331000, 546/268400, 548/138000, 548/143000, 548/233000, 548/255000

Abstract:

The present invention relates to 4-aryl triazoles having the formula: wherein Ris independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR, SR, S(O)R, S(O)R, and NRR; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.

US Patent:

20030162778, Aug 28, 2003

Filed:

Sep 18, 2002

Appl. No.:

10/246496

Inventors:

Michael Natchus - Alpharetta GA, US
Stanislaw Pikul - Germantown MD, US
Neil Almstead - Holmdel NJ, US
Matthew Laufersweiler - Morrow OH, US
Roger Bookland - Cincinnati OH, US
Joshua Tullis - Broomfield CO, US
Biswanath De - Cincinnati OH, US

Assignee:

The Procter and Gamble Company

International Classification:

A61K031/537
A61K031/4015
A61K031/195
C07D207/12

US Classification:

514/228800, 514/237500, 514/562000, 514/424000, 544/158000, 548/543000, 562/430000

Abstract:

The compounds have a structure according to the following Formula (I): are effective in treating conditions characterized by excess activity of these enzymes.