Joyce W Reid

US Patent:

47389788, Apr 19, 1988

Filed:

Nov 10, 1986

Appl. No.:

6/928947

Inventors:

Masami Nakane - Aichi, JP
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D30700
C07D40506
A61K 3134
A61K 3141

US Classification:

514382

Abstract:

Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH. dbd. CH-- or --CH. sub. 2 --CH. sub. 2 --; n is 1 to 5; R is CO. sub. 2 H, CO. sub. 2 lower alkyl or ##STR2## q is 1 to 12; and R. sup. 1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-aryl-S-, arylalkyl-S-, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

47344245, Mar 29, 1988

Filed:

Sep 24, 1986

Appl. No.:

6/911173

Inventors:

Steven E. Hall - Ewing Township, Mercer County NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C17700
A61K 31557

US Classification:

514382

Abstract:

Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH. dbd. CH-- or --CH. sub. 2 --CH. sub. 2 --; n is 1 to 5; Q is --CH. dbd. CH--, --CH. sub. 2 --, ##STR2## or a single bond; R is CO. sub. 2 H, CO. sub. 2 alkyl, CO. sub. 2 alkali metal, CO. sub. 2 polyhydroxyamine salt, --CH. sub. 2 OH, ##STR3## wherein R. sup. 4 and R. sup. 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R. sup. 4 and R. sup. 5 being other than hydroxy and lower alkoxy; p is 1 to 4; R. sup. 1 is H or lower alkyl; q is 1 to 12; R. sup. 2 is H or lower alkyl; and R. sup. 3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

47344253, Mar 29, 1988

Filed:

Oct 17, 1986

Appl. No.:

6/920006

Inventors:

Masami Nakane - Aichi, JP
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D30700
C07D40506
A61K 3134
A61K 3141

US Classification:

514382

Abstract:

7-Oxabicycloheptane substituted hydroxamic acid prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH. dbd. CH-- or --CH. sub. 2 -CH. sub. 2 --; n is 1 to 5; R is CO. sub. 2 H, CO. sub. 2 alkyl, CO. sub. 2 alkali metal, CO. sub. 2 polyhydroxyamine salt, --CH. sub. 2 OH, ##STR2## wherein R. sup. 4 and R. sup. 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R. sup. 4 and R. sup. 5 being other than hydroxy and lower alkoxy; q is 1 to 12, R. sup. 1 is H or OH; R. sup. 2 is OH or H, provided that one of R. sup. 1 and R. sup. 2 is OH and the other is H; and R. sup. 3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

41661834, Aug 28, 1979

Filed:

Mar 23, 1978

Appl. No.:

5/889471

Inventors:

Frederic P. Hauck - Bridgewater NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D21520
C07D21702

US Classification:

546101

Abstract:

Compounds having the formula ##STR1## wherein R. sub. 1 is alkanoyl; and one of R. sub. 2, R. sub. 3 and R. sub. 4 is ##STR2## wherein R. sub. 5 is alkyl, and the other groups are --CH. sub. 2 --; have useful hypotensive activity.

US Patent:

41277171, Nov 28, 1978

Filed:

Mar 20, 1978

Appl. No.:

5/888128

Inventors:

Frederic P. Hauck - Bridgewater NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D29510

US Classification:

544154

Abstract:

Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R. sub. 1 is alkanoyl; and R. sub. 2 is a tertiary amino group; have hypotensive activity.

US Patent:

41567234, May 29, 1979

Filed:

Aug 4, 1977

Appl. No.:

5/821889

Inventors:

Frederic P. Hauck - Bridgewater NJ
Michael E. Condon - Lawrenceville NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3113
A61K 31495

US Classification:

424244

Abstract:

Compounds are provided having the structure ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3 or R. sub. 4 is hydrogen or acyl, and R. sub. 5 is hydrogen or acyl, X is a straight or branched bivalent alkylene radical and Y is ##STR2## These compounds are useful in the treatment of hypertension.

US Patent:

41736400, Nov 6, 1979

Filed:

Aug 4, 1977

Appl. No.:

5/821891

Inventors:

Frederic P. Hauck - Bridgewater NJ
Michael E. Condon - Lawrenceville NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31445
C07D21134

US Classification:

424267

Abstract:

Compounds are provided having the structure ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3 or R. sub. 4 is hydrogen or acyl and R. sub. 5 is hydrogen or acyl, X is a straight or branched bivalent alkylene radical and Y is ##STR2## These compounds are useful in the treatment of hypertension.

US Patent:

43179100, Mar 2, 1982

Filed:

Aug 14, 1978

Appl. No.:

5/933227

Inventors:

Frederic P. Hauck - Bridgewater NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C 8728
C07D29510

US Classification:

544154

Abstract:

Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; and R. sub. 2 is a tertiary amino group; are intermediates useful in the preparation of compounds having hypotensive activity.