Joyce M Reid

US Patent:

40814440, Mar 28, 1978

Filed:

Jan 21, 1977

Appl. No.:

5/761103

Inventors:

Michael E. Condon - Lawrenceville NJ
Frederic P. Hauck - Somerville NJ
Joyce Reid - Highland Park NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D29514

US Classification:

260268PH

Abstract:

Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R. sub. 1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R. sub. 2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R. sub. 3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharamacological properties.

US Patent:

44168969, Nov 22, 1983

Filed:

May 17, 1982

Appl. No.:

6/378560

Inventors:

Masami Nakane - Plainsboro NJ
David L. Snitman - Boulder CO
Joyce Reid - Dayton NJ
Martin F. Haslanger - Lambertville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3134
C07D30700

US Classification:

424285

Abstract:

7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

US Patent:

44566158, Jun 26, 1984

Filed:

Oct 25, 1982

Appl. No.:

6/436741

Inventors:

Masami Nakane - Plainsboro NJ
David L. Snitman - Boulder CO
Joyce Reid - Dayton NJ
Martin F. Haslanger - Lambertville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3134
C07D30700

US Classification:

424285

Abstract:

7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

US Patent:

46543562, Mar 31, 1987

Filed:

Aug 1, 1985

Appl. No.:

6/761263

Inventors:

Masami Nakane - Hopewell NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D49308
C07D40514
A61K 3134
A61K 314

US Classification:

514382

Abstract:

7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH. dbd. CH-- or --CH. sub. 2 --CH. sub. 2 --; n is 1 to 5; Q is --CH. dbd. CH--, --CH. sub. 2 --, ##STR2## or a single bond; R is CO. sub. 2 H, CO. sub. 2 alkyl, CO. sub. 2 alkali metal, CO. sub. 2 polyhydroxyamine salt, --CH. sub. 2 OH, ##STR3## wherein R. sup. 4 and R. sup. 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R. sup. 4 and R. sup. 5 being other than hydroxy and lower alkoxy; p is 1 to 4; R. sup. 1 is H or lower alkyl; q is 1 to 12; R. sup. 2 and R. sup. 3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy or cycloalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

46543554, Mar 31, 1987

Filed:

Aug 1, 1985

Appl. No.:

6/761261

Inventors:

Masami Nakane - Hopewell NJ
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D44308
C07D40514
A61K 3134
A61K 3141

US Classification:

514382

Abstract:

7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH. dbd. CH-- or --CH. sub. 2 CH. sub. 2 --; n is 1 to 5; Q is --CH. dbd. CH--, --CH. sub. 2 --, ##STR2## or a single bond; R is CO. sub. 2 H, CO. sub. 2 alkyl, CO. sub. 2 alkali metal, CO. sub. 2 polyhydroxyamine salt, --CH. sub. 2 OH, ##STR3## wherein R. sup. 4 and R. sup. 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R. sup. 4 and R. sup. 5 being other than hydroxy and lower alkoxy; p is 1 to 4; R. sup. 1 is H or lower alkyl; q is 1 to 12; R. sup. 2 is H or lower alkyl; and R. sup. 3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, amino, alkylamino, or arylamino. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

40187730, Apr 19, 1977

Filed:

Sep 15, 1975

Appl. No.:

5/613721

Inventors:

Michael E. Condon - Lawrenceville NJ
Frederic P. Hauck - Somerville NJ
Joyce Reid - Highland Park NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D29508

US Classification:

260268PH

Abstract:

Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R. sub. 1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R. sub. 2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R. sub. 3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharmacological properties.

US Patent:

44180764, Nov 29, 1983

Filed:

May 3, 1982

Appl. No.:

6/374125

Inventors:

Masami Nakane - Plainsboro NJ
Joyce Reid - Dayton NJ
Martin F. Haslanger - Lambertville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3134
C07D30700

US Classification:

424285

Abstract:

7-Oxabicycloheptane hydrazone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. pa The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.