Joyce L Reid

US Patent:

41384970, Feb 6, 1979

Filed:

Jul 29, 1977

Appl. No.:

5/820290

Inventors:

Frederic P. Hauck - Somerville NJ
Joseph E. Sundeen - Yardley PA
Joyce Reid - Highland Park NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3113
A61K 31215
C07C 6700
C07C10300

US Classification:

424305

Abstract:

Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R. sub. 1 R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxylakylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

US Patent:

40923185, May 30, 1978

Filed:

Mar 15, 1976

Appl. No.:

5/666983

Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D21122

US Classification:

26029356

Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

US Patent:

47389788, Apr 19, 1988

Filed:

Nov 10, 1986

Appl. No.:

6/928947

Inventors:

Masami Nakane - Aichi, JP
Joyce Reid - Dayton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D30700
C07D40506
A61K 3134
A61K 3141

US Classification:

514382

Abstract:

Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH. dbd. CH-- or --CH. sub. 2 --CH. sub. 2 --; n is 1 to 5; R is CO. sub. 2 H, CO. sub. 2 lower alkyl or ##STR2## q is 1 to 12; and R. sup. 1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-aryl-S-, arylalkyl-S-, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

US Patent:

40440400, Aug 23, 1977

Filed:

Mar 15, 1976

Appl. No.:

5/667003

Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C14368
C07C 3302
C07C 3532
C07C 3536

US Classification:

260456P

Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

US Patent:

40814440, Mar 28, 1978

Filed:

Jan 21, 1977

Appl. No.:

5/761103

Inventors:

Michael E. Condon - Lawrenceville NJ
Frederic P. Hauck - Somerville NJ
Joyce Reid - Highland Park NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D29514

US Classification:

260268PH

Abstract:

Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R. sub. 1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R. sub. 2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R. sub. 3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharamacological properties.

US Patent:

44168969, Nov 22, 1983

Filed:

May 17, 1982

Appl. No.:

6/378560

Inventors:

Masami Nakane - Plainsboro NJ
David L. Snitman - Boulder CO
Joyce Reid - Dayton NJ
Martin F. Haslanger - Lambertville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3134
C07D30700

US Classification:

424285

Abstract:

7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

US Patent:

44566158, Jun 26, 1984

Filed:

Oct 25, 1982

Appl. No.:

6/436741

Inventors:

Masami Nakane - Plainsboro NJ
David L. Snitman - Boulder CO
Joyce Reid - Dayton NJ
Martin F. Haslanger - Lambertville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3134
C07D30700

US Classification:

424285

Abstract:

7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.

US Patent:

40535967, Oct 11, 1977

Filed:

Jan 14, 1976

Appl. No.:

5/649116

Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D21114
A61K 31445

US Classification:

424244

Abstract:

Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.