Frederic P. Hauck - Somerville NJ Joseph E. Sundeen - Yardley PA Joyce Reid - Highland Park NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
A61K 3113 A61K 31215 C07C 6700 C07C10300
US Classification:
424305
Abstract:
Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R. sub. 1 R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxylakylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.
Frederic Peter Hauck - Somerville NJ Joyce Reid - Highland Park NJ Venkatachala L. Narayanan - Hightstown NJ Christopher M. Cimarusti - Hamilton NJ Rudiger D. Haugwitz - Titusville NJ Joseph E. Sundeen - Yardley PA
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07D21122
US Classification:
26029356
Abstract:
Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.
4,7-Dihydroindanyl Alkanols, Analogues Thereof And Their Corresponding Tosylates
Frederic Peter Hauck - Somerville NJ Joyce Reid - Highland Park NJ Venkatachala L. Narayanan - Hightstown NJ Christopher M. Cimarusti - Hamilton NJ Rudiger D. Haugwitz - Titusville NJ Joseph E. Sundeen - Yardley PA
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07C14368 C07C 3302 C07C 3532 C07C 3536
US Classification:
260456P
Abstract:
Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.
Frederic Peter Hauck - Somerville NJ Joyce Reid - Highland Park NJ Venkatachala L. Narayanan - Hightstown NJ Christopher M. Cimarusti - Hamilton NJ Rudiger D. Haugwitz - Titusville NJ Joseph E. Sundeen - Yardley PA
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07D21114 A61K 31445
US Classification:
424244
Abstract:
Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.
Frederic P. Hauck - Somerville NJ Joyce Reid - Highland Park NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07C12147 C07C 6902 A61K 3113
US Classification:
260464
Abstract:
Compounds having the structure ##STR1## wherein R. sub. 1 is alkyl or arylalkyl; R. sub. 2 is --C. tbd. N, --C. tbd. CH or ##STR2## wherein R. sub. 4 is hydrogen, alkyl, aryl, or arylalkyl; R. sub. 3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.
Compounds having the formula ##STR1## wherein R. sub. 1 is alkanoyl; and one of R. sub. 2, R. sub. 3 and R. sub. 4 is ##STR2## wherein R. sub. 5 is alkyl, and the other groups are --CH. sub. 2 --; have useful hypotensive activity.
Frederic P. Hauck - Somerville NJ Joyce Reid - Highland Park NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07C 9300 C07C 9324
US Classification:
560252
Abstract:
Compounds having the structure ##STR1## wherein R. sub. 1 is alkyl or arylalkyl; R. sub. 2 is --C. tbd. N, --C. tbd. CH or ##STR2## wherein R. sub. 4 is hydrogen, alkyl, aryl, or arylalkyl; R. sub. 3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.
Frederic P. Hauck - Somerville NJ Joseph E. Sundeen - Yardley PA Joyce Reid - Highland Park NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07C 9300 C07C 9312
US Classification:
260490
Abstract:
Compounds having the structure ##SPC1## Wherein R. sub. 1 is alkyl or arylalkyl; R. sub. 2 is hydrogen, halogen, alkyl, or alkoxy; R. sub. 3 is alkanoyl; R. sub. 4 is hydrogen or alkanoyl; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4; are useful for the treatment of hypertension.
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