Judith Ann Kantor

US Patent:

6548068, Apr 15, 2003

Filed:

Jan 7, 2000

Appl. No.:

09/480340

Inventors:

Jeffrey Schlom - Potamac MD
Judith Kantor - Rockville MD
James W. Hodge - Gaithersburg MD

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 3900

US Classification:

4241991, 4242321, 4242041, 4353201, 4352351, 435325, 530350, 5303871, 536 2372

Abstract:

The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

US Patent:

6893869, May 17, 2005

Filed:

Jan 14, 2003

Appl. No.:

10/341431

Inventors:

Jeffrey Schlom - Potamac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

C12N005/00

US Classification:

435325, 4352351, 435 691, 4353201

Abstract:

The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

US Patent:

7118738, Oct 10, 2006

Filed:

Jan 25, 2002

Appl. No.:

10/057136

Inventors:

Jeffrey Schlom - Potomac MD, US
Judith Kantor - Rockville MD, US
Donald Kufe - Wellesley MA, US
Dennis Panicali - Acton MA, US
Linda Gritz - Somerville MA, US

Assignee:

Therion Biologics Corporation - Cambridge MA
Dana-Farber Cancer Institute - Boston MA
The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A01N 63/00
A61K 48/00
C12N 15/00
C12N 15/09
C12N 15/63
C12N 15/70
C12N 15/74

US Classification:

424 932, 4353201

Abstract:

Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e. g. , to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.

US Patent:

7368116, May 6, 2008

Filed:

Mar 28, 2005

Appl. No.:

11/090686

Inventors:

Jeffrey Schlom - Potomac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 39/12

US Classification:

4241991, 4242321, 4242041, 435 691

Abstract:

The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

US Patent:

7662395, Feb 16, 2010

Filed:

Apr 30, 2008

Appl. No.:

12/112819

Inventors:

Jeffrey Schlom - Potomac MD, US
Judith Kantor - Rockville MD, US
James W. Hodge - Gaithersburg MD, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 39/12

US Classification:

4241991, 4353201

Abstract:

The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.

US Patent:

7829678, Nov 9, 2010

Filed:

Nov 7, 2008

Appl. No.:

12/266889

Inventors:

J. Andrew Bristol - Bethesda MD, US
Judith A. Kantor - Rockville MD, US

Assignee:

Neogenix Oncology, Inc. - Rockville MD

International Classification:

C12P 21/08
C07K 16/00
C07K 17/00
C07K 17/14
A61K 39/00
A61K 39/395

US Classification:

5303881, 5303871, 5303888, 5303911, 5303913, 4241331, 4241341, 4241381, 4241411, 4241551, 4241781

Abstract:

The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.

US Patent:

8524456, Sep 3, 2013

Filed:

Aug 19, 2010

Appl. No.:

12/859526

Inventors:

J. Andrew Bristol - Bethesda MD, US
Judith A. Kantor - Rockville MD, US

Assignee:

Precision Biologics, Inc. - Dallas TX

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.

US Patent:

20090155232, Jun 18, 2009

Filed:

Jul 14, 2008

Appl. No.:

12/218301

Inventors:

Jaya Gaddipati - Boyds MD, US
Judith Kantor - Rockville MD, US
Yvonne A. Reid - Haymarket VA, US

Assignee:

American Type Culture Collection - Manassas VA

International Classification:

A61K 48/00
C12N 5/10
C12N 15/85
C12Q 1/02

US Classification:

424 9321, 435370, 435455, 435 29

Abstract:

The present invention relates to the discovery of immortalized neonatal human hepatocytes that exhibit phenotypic features of human hepatic progenitor cells. The invention is also directed to a method of obtaining telomerase-immortalized neonatal human hepatocytes that exhibit phenotypic features of human hepatic progenitor cells. Furthermore, the instant invention describes methods of using the immortalized neonatal human hepatocytes in cellular therapies, toxicological studies, pharmacokinetic studies, metabolic studies, therapeutic gene delivery and for the production of fully differentiated hepatocytes.