Judith P Kitchell

US Patent:

54035953, Apr 4, 1995

Filed:

Oct 13, 1993

Appl. No.:

8/135847

Inventors:

Judith P. Kitchell - Newton MA
Indu A. Muni - N. Reading MA
Yvonne N. Boyer - Salem MA

Assignee:

DynaGen, Inc. - Cambridge MA

International Classification:

A61K 950
A61K 970
A61K 948

US Classification:

424501

Abstract:

A drug delivery system useful in aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS. TM. ) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems and kits containing the drug delivery systems.

US Patent:

47724846, Sep 20, 1988

Filed:

Jun 17, 1987

Appl. No.:

7/063583

Inventors:

Judith P. Kitchell - Newton MA
Stanton R. de Riel - Pembroke Pines FL

International Classification:

A01N 102

US Classification:

427 2

Abstract:

Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.

US Patent:

55365035, Jul 16, 1996

Filed:

Apr 3, 1995

Appl. No.:

8/415859

Inventors:

Judith P. Kitchell - Newton MA
Indu A. Muni - N. Reading MA
Yvonne N. Boyer - Salem MA

Assignee:

DynaGen, Inc. - Cambridge MA

International Classification:

A61K 970
A61K 948
A61K 950
A61F 202

US Classification:

424449

Abstract:

A drug delivery system useful in aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS. TM. ) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems and kits containing the drug delivery systems.

US Patent:

56562985, Aug 12, 1997

Filed:

Feb 28, 1995

Appl. No.:

8/396363

Inventors:

Judith P. Kitchell - Newton MA
Stephen C. Crooker - Framingham MA

Assignee:

DynaGen, Inc. - Cambridge MA

International Classification:

A61K 914

US Classification:

424486

Abstract:

An immunobooster capable of delivering an immunogen to an individual or animal in a controlled release manner is described. The immunobooster contains an immunogen/hydrophobic polymer matrix with a swelling agent such that the swelling agent can swell in an aqueous environment and burst the matrix. The immunogen is released in a pulsed release manner after a desired time interval has elapsed subsequent to administration of the immunobooster. The immunobooster eliminates the need for multiple administrations of immunogen in order to build lasting immunity. Also described are methods of preparing and using the immunobooster, and kits containing the immunobooster.

US Patent:

46923284, Sep 8, 1987

Filed:

Sep 24, 1985

Appl. No.:

6/780162

Inventors:

Judith P. Kitchell - Newton MA
Stanton R. de Riel - Pembroke Pines FL

Assignee:

Dynatech Corporation - Cambridge MA

International Classification:

A61K 3174

US Classification:

424 78

Abstract:

Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.

US Patent:

48942316, Jan 16, 1990

Filed:

Jul 28, 1987

Appl. No.:

7/078534

Inventors:

Jacques-Pierre Moreau - Upton MA
Judith P. Kitchell - Newton MA

Assignee:

Biomeasure, Inc. - Hopkinton MA

International Classification:

A61F 200
A61K 914

US Classification:

424426

Abstract:

A therapeutic agent delivery system that includes a biodegradable polymer and a therapeutic agent, the delivery system being coated with a barrier substance that decreases the quantity of the agent released from the system, compared to the quantity of the agent released from a system not coated with the substance, in the forty-eight hours subsequent to the parenteral injection or implantation of the system into a living person or animal.

US Patent:

54863627, Jan 23, 1996

Filed:

Oct 21, 1993

Appl. No.:

8/140280

Inventors:

Judith P. Kitchell - Newton MA
Indu A. Muni - N. Reading MA
Yvonne N. Boyer - Salem MA

Assignee:

DynaGen, Inc. - Cambridge MA

International Classification:

A61F 202
A61K 970
A61K 948
A61K 950

US Classification:

424426

Abstract:

A drug delivery system useful in treating an individual for a drug dependence is described. One embodiment of the system is useful for aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS. TM. ) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems in treating other drug dependencies and kits containing the drug delivery systems.