Michael D. Varney - Carlsbad CA Cindy L. Palmer - La Mesa CA Judy G. Deal - Temecula CA
Assignee:
Agouron Pharmaceuticals, Inc. - La Jolla CA
International Classification:
C07C25552
US Classification:
558418
Abstract:
The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: ##STR1## The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyano-naphthalene compound and its precursors are also described.
Preparation Of Benzindole Compounds From Naphthalene Compounds
Michael D. Varney - Carlsbad CA Cindy L. Palmer - La Mesa CA Judy G. Deal - Temecula CA
Assignee:
Agouron Pharmaceuticals, Inc. - La Jolla CA
International Classification:
C07D20962
US Classification:
548436
Abstract:
The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: ##STR1## The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyanonaphthalene compound and its precursors are also described.
Aragon Avenue Elementary School Los Angeles CA 1956-1957, Garvanza Elementary School Los Angeles CA 1957-1963, Luther Burbank Middle School Los Angeles CA 1964-1966