Jui I Lin

US Patent:

20120264109, Oct 18, 2012

Filed:

Mar 28, 2012

Appl. No.:

13/432542

Inventors:

Chiranjit DEKA - Morrisville NC, US
Jui Ming LIN - Falmouth ME, US
Mary GOYETTE - Somersworth NH, US

Assignee:

IDEXX LABORATORIES, INC. - Westbrook ME

International Classification:

G01N 33/566

US Classification:

435 5

Abstract:

The present disclosure describes a method of monitoring disease progression in a mammal positive for immunodeficiency virus which includes collecting blood cells from a mammal to obtain a first blood sample adding antibodies such as CD4 and CD8 to the first blood sample scanning the blood sample to produce a first multivariate dot plot which may be used to quantify at least CD4 and CD8 blood cell populations to produce a first ratio. The first multivariate dot plot may also be used to quantify a CD8αβsubpopulation which may be used to calculate a second ratio. A third ratio is calculated of the second ratio to the first ratio and the result plotted on a graph as a first point. This process may be repeated to produce a second point for evaluating an extent of disease progression.