Julia K Wang

US Patent:

7026285, Apr 11, 2006

Filed:

May 19, 2004

Appl. No.:

10/848779

Inventors:

Arthur O. Tzianabos - Reading MA, US
Dennis L. Kasper - Charleston MA, US
Andrew B. Onderdonk - Westwood MA, US
Julia Ying Wang - Brookline MA, US

Assignee:

The Bingham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 47/36
A61K 47/42

US Classification:

514 2, 514 72, 424 9322, 4241921, 530530, 530402

Abstract:

Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.

US Patent:

7252828, Aug 7, 2007

Filed:

Jan 26, 2001

Appl. No.:

09/771003

Inventors:

Gerald B. Pier - Brookline MA, US
Julia Y. Wang - Chestnut Hill MA, US
David McKenney - Quincy MA, US

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/02
A61K 39/09
A61K 39/00
A61K 31/70
C07H 1/00
C07H 1/06
A01N 43/04

US Classification:

4242341, 4242371, 4241841, 424831, 5361231, 536127, 514 23, 514 54, 514 62

Abstract:

The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. The invention also relates to the use of the PS/A as a vaccine for inducing active immunity to infections caused by , other related coagulase-negative and organisms carrying the ica (intracellular adhesin) locus, and to the use of antibodies directed to PS/A for inducing passive immunity to the same class of infections.

US Patent:

8008276, Aug 30, 2011

Filed:

May 22, 2009

Appl. No.:

12/470985

Inventors:

Julia Ying Wang - Brookline MA, US
Michael H. Roehrl - Brookline MA, US
Dennis L. Kasper - Brookline MA, US

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A01N 43/04
A61K 31/715

US Classification:

514 54, 5361231

Abstract:

The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design, and immunomodulatory polymers. In particular the invention is directed to immunomodulatory polymers, as well as to methods for designing, selecting, and screening therapeutic agents having immunomodulatory activity.

US Patent:

20100260801, Oct 14, 2010

Filed:

Dec 22, 2006

Appl. No.:

11/645220

Inventors:

Gerald B. Pier - Brookline MA, US
Julia Y. Wang - Chestnut Hill MA, US
David McKenney - Quincy MA, US

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61K 39/085
C07H 1/00
A61P 31/04

US Classification:

4242431, 5361231

Abstract:

The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. The invention also relates to the use of the PS/A as a vaccine for inducing active immunity to infections caused by , other related coagulase-negative staphylococci and organisms carrying the ica (intracellular adhesin) locus, and to the use of antibodies directed to PS/A for inducing passive immunity to the same class of infections.

US Patent:

20160331875, Nov 17, 2016

Filed:

Nov 26, 2014

Appl. No.:

15/039136

Inventors:

- Boston MA, US
Jonah Andrew KAPLAN - Newton MA, US
Julia WANG - Forest Hills NY, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY - Boston MA

International Classification:

A61L 31/14
A61L 29/14
A61L 29/16
A61L 27/54
A61L 31/16
A61L 27/34
A61L 27/50
A61L 29/08
A61L 31/10

Abstract:

The disclosure provides a drug delivery device that can release a drug or other molecule of interest in response to application of a mechanical force, such as tension, and methods of use thereof. The present disclosure provides a tension-responsive drug delivery device by exploiting a difference in mechanical properties between a drug-loaded core material and a supertiydrophobic barrier coating consisting of interconnected micro- and nano-sized particles formulated via the electrospraying of a mixture of biocompatible polymers.