Lewis Williams - Mill Valley CA, US Jaime Escobedo - Alamo CA, US Michael Innis - Moraga CA, US Pablo Garcia - San Francisco CA, US Julie Klinger - Kensington CA, US Christoph Reinhard - Alameda CA, US Zhijun He - Ithaca NY, US Filippo Randazzo - Oakland CA, US Giulia Kennedy - San Francisco CA, US David Pot - Arlington VA, US Altaf Kassam - Oakland CA, US George Lamson - Moraga CA, US Radjoe Drmanac - Palo Alto CA, US Mark Dickson - Hollister CA, US Ivan Labat - Mountain View CA, US Lee Jones - Sunnyvale CA, US
This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
Christoph Reinhard - Alameda CA, US Julie Klinger - Kensington CA, US Ann Jefferson - Oakland CA, US Jaime Escobedo - Alamo CA, US Fillipo Randazzo - Emeryville CA, US Jill Winter - Richmond CA, US Robert Goodson - Richmond CA, US Weimin Qi - Moraga CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12Q 1/68 A61K 39/395
US Classification:
424155100, 435006000
Abstract:
Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P-cadherin antibodies. Also provided are screens for identifying anti-P-cadherin antibodies having therapeutic activity.
Christoph Reinhard - Alameda CA, US Julie Klinger - Kensington CA, US Ann Jefferson - Oakland CA, US Jaime Escobedo - Alamo CA, US Fillipo Randazzo - Emeryville CA, US Jill Winter - Richmond CA, US Robert Goodson - Richmond CA, US Weimin Qi - Moraga CA, US
Assignee:
CHIRON Corporation - Emeryville CA
International Classification:
A61K039/395 A61K031/00
US Classification:
424/155100, 514/001000
Abstract:
Method of treating or diagnosing cancers involving P-cadherin expression are provided using ligands that target P-cadherin, especially human anti-P-cadherin antibodies. Also provided are screens for identifying anti-P-cadherin antibodies having therapeutic activity.