- Rahway NJ, US Chitrananda Abeygunawardana - Ambler PA, US Luwy Kavuka Musey - Blue Bell PA, US Michael J. Kosinski - Souderton PA, US Yadong Adam Cui - Norristown PA, US Julie Marie Skinner - Phoenixville PA, US
Assignee:
Merck Sharp & Dohme LLC - Rahway NJ
International Classification:
A61K 39/09 A61K 39/39 A61K 47/42
Abstract:
The present invention provides capsular polysaccharides from serotypes identified using NMR The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.
Pneumococcal Polysaccharides And Their Use In Immunogenic Polysaccharide-Carrier Protein Conjugates
- Rahway NJ, US Chitrananda Abeygunawardana - Ambler PA, US Luwy Kavuka Musey - Blue Bell PA, US Michael J. Kosinski - Souderton PA, US Yadong Adam Cui - Norristown PA, US Julie Marie Skinner - Phoenixville PA, US
Assignee:
Merck Sharp & Dohme LLC - Rahway NJ
International Classification:
A61K 39/09 A61K 39/39 A61K 47/42
Abstract:
The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.
Pneumococcal Polysaccharides And Their Use In Immunogenic Polysaccharide-Carrier Protein Conjugates
- Rahway NJ, US Chitrananda Abeygunawardana - Ambler PA, US Luwy Kavuka Musey - Blue Bell PA, US Michael J. Kosinski - Souderton PA, US Yadong Adam Cui - Norristown PA, US Julie Marie Skinner - Phoenixville PA, US
Assignee:
Merck Sharp & Dohme LLC - Rahway NJ
International Classification:
A61K 39/09 A61K 39/39 A61K 47/42
Abstract:
The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.
Pneumococcal Polysaccharides And Their Use In Immunogenic Polysaccharide-Carrier Protein Conjugates
- Rahway NJ, US Chitrananda Abeygunawardana - Ambler PA, US Luwy Kavuka Musey - Blue Bell PA, US Michael J. Kosinski - Souderton PA, US Yadong Adam Cui - Norristown PA, US Julie Marie Skinner - Phoenixville PA, US
Assignee:
Merck Sharp & Dohme LLC - Rahway NJ
International Classification:
A61K 39/09 A61K 39/39 A61K 47/42
Abstract:
The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.
Pneumococcal Polysaccharides And Their Use In Immunogenic Polysaccharide-Carrier Protein Conjugates
- Rahway NJ, US Chitrananda Abeygunawardana - Ambler PA, US Luwy Kavuka Musey - Blue Bell PA, US Michael J. Kosinski - Souderton PA, US Yadong Adam Cui - Norristown PA, US Julie Marie Skinner - Phoenixville PA, US
Assignee:
Merck Sharp & Dohme LLC - Rahway NJ
International Classification:
A61K 39/09 A61K 39/39 A61K 47/42
Abstract:
The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional serotypes.
Compositions Comprising Streptococcus Pneumoniae Polysaccharide-Protein Conjugates And Methods Of Use Thereof
- Rahway NJ, US Patrick McHugh - Pipersville PA, US Michael A. Winters - Doylestown PA, US Julie M. Skinner - Phoenixville PA, US Jian He - Blue Bell PA, US Luwy Musey - Blue Bell PA, US Chitrananda Abeygunawardana - Ambler PA, US Yadong Adam Cui - Norristown PA, US Michael J. Kosinski - Souderton PA, US
The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an serotype conjugated to a carrier protein, wherein the serotypes of are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against infection and diseases caused by . The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
Compositions Comprising Streptococcus Pneumoniae Polysaccharide-Protein Conjugates And Methods Of Use Thereof
- Rahway NJ, US Patrick McHugh - Pipersville PA, US Michael Albert Winters - Doylestown PA, US Julie M. Skinner - Phoenixville PA, US Jian He - Blue Bell PA, US Luwy Musey - Blue Bell PA, US Chitrananda Abeygunawardana - Ambler PA, US Yadong Adam Cui - Norristown PA, US Michael J. Kosinski - Souderton PA, US
The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an serotype conjugated to a carrier protein, wherein the serotypes of are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against infection and diseases caused by The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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