Jun Zhou

US Patent:

20190375818, Dec 12, 2019

Filed:

Mar 27, 2019

Appl. No.:

16/365978

Inventors:

- Boston MA, US
Jun Zhou - Waltham MA, US
Gordon J. Freeman - Brookline MA, US
Jingjing Li - Lexington MA, US
Xinqi Wu - Chestnut Hill MA, US

International Classification:

C07K 14/705
C12Q 1/6886
C07K 16/28
A61K 45/06
A61K 39/395
A61K 38/17
A61K 9/00
G01N 33/574
G01N 33/50
C07K 16/30

Abstract:

The present invention relates to compositions and methods for identifying, assessing, preventing, and treating melanoma. A variety of PD-L1 isoform biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with melanoma status.

US Patent:

20190210016, Jul 11, 2019

Filed:

Jan 3, 2019

Appl. No.:

16/238986

Inventors:

- WOBURN MA, US
Jeff KROGMEIER - Winchester MA, US
Andrew GOLDEN - Boston MA, US
Samrudhi SHARMA - Billerica MA, US
Laurent MENARD - Raleigh NC, US
Andrew WATSON - Bedford MA, US
Oscar MCCRATE - Detroit MI, US
Jun ZHOU - Belmont MA, US
Rachel ROWELL - Salem MA, US

International Classification:

B01L 3/00
C12Q 1/68
G01N 27/447

Abstract:

A fluidic chip for detecting an analyte is provided, which comprises (a) at least one device comprising (i) a fluid inlet and (ii) at least one fluid transport channel that passes through a detection region, wherein (1) the at least one fluid transport channel has varying cross-sectional area as a function of position along the channel length and/or (2) the device comprises two or more fluid transport channels configured with two or more different cross-sectional areas; and (b) at least one fluid outlet, wherein the device provides for transport of single molecules across the detection region at a desired duty cycle by (1) allowing for detection of an analyte at a different position along the channel length based on the desired cross-sectional area and/or (2) allowing for detection of an analyte in a specific channel configured with the desired cross-sectional area. This application also provides for method of optimizing duty cycle using fluidic chips.

US Patent:

20170248603, Aug 31, 2017

Filed:

Oct 5, 2015

Appl. No.:

15/516774

Inventors:

- Boston MA, US
Jun Zhou - Waltham MA, US
Xinqi Wu - Chestnut Hill MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

G01N 33/574
C12Q 1/68
G01N 33/50

Abstract:

The present invention is based on the identification of novel biomarkers predictive of responsiveness to anti-immune checkpoint therapies.

US Patent:

20160340407, Nov 24, 2016

Filed:

Jan 14, 2015

Appl. No.:

15/110808

Inventors:

- Boston MA, US
Jun Zhou - Waltham MA, US
Gordon J. Freeman - Brookline MA, US
Jingjing Li - Lexington MA, US
Xinqi Wu - Chestnut Hill MA, US

Assignee:

Dana-Farber Camcer Institute, Inc. - Boston MA

International Classification:

C07K 14/705
A61K 9/00
C07K 16/28
G01N 33/574
C07K 16/30
A61K 38/17
G01N 33/50
C12Q 1/68
A61K 45/06
A61K 39/395

Abstract:

The present invention relates to compositions and methods for identifying, assessing, preventing, and treating melanoma, A variety of PD-L1 isoform biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with melanoma status.