Justin E Nelson

US Patent:

20220334075, Oct 20, 2022

Filed:

Apr 13, 2022

Appl. No.:

17/719760

Inventors:

- Minneapolis MN, US
- Maple Grove MN, US
Philippe Pierre Joseph Buhlmann - Minneapolis MN, US
Xue Zhen - Plymouth Meeting PA, US
Justin Theodore Nelson - Vadnais Heights MN, US
Gregory J. Sherwood - North Oaks MN, US

International Classification:

G01N 27/22
G01N 33/497

Abstract:

Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.

US Patent:

20220291198, Sep 15, 2022

Filed:

Mar 29, 2022

Appl. No.:

17/707214

Inventors:

- Maple Grove MN, US
- Minneapolis MN, US
Steven J. Koester - Edina MN, US
Justin Theodore Nelson - Vadnais Heights MN, US

International Classification:

G01N 33/497
G01N 27/12
G01N 27/22

Abstract:

Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

US Patent:

20210369250, Dec 2, 2021

Filed:

May 24, 2021

Appl. No.:

17/328478

Inventors:

- Minneapolis MN, US
- Maple Grove MN, US
Justin Theodore Nelson - Minneapolis MN, US
Xue Zhen - Minneapolis MN, US

International Classification:

A61B 10/00
C01B 32/194
C01G 7/00

Abstract:

Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor. The graphene varactor includes a graphene layer and at least one non-covalent modification layer disposed on an outer surface of the graphene layer. The non-covalent modification layer can include nanoparticles selected from a group that can include one or more metals, metal oxides, or derivatives thereof. Other embodiments are also included herein.

US Patent:

20210356457, Nov 18, 2021

Filed:

Jul 28, 2021

Appl. No.:

17/387503

Inventors:

- Maple Grove MN, US
- Minneapolis MN, US
Steven Koester - Edina MN, US
Yao Zhang - Minneapolis MN, US
Justin Theodore Nelson - Minneapolis MN, US

International Classification:

G01N 33/53
G01N 27/12
G01N 27/22

Abstract:

Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

US Patent:

20210341409, Nov 4, 2021

Filed:

Apr 28, 2021

Appl. No.:

17/242750

Inventors:

- Maple Grove MN, US
Vijay Koya - Blaine MN, US
August Judisch - Minneapolis MN, US
Gregory J. Sherwood - North Oaks MN, US
Kate Louise Frost - New Brighton MN, US
Justin Theodore Nelson - Minneapolis MN, US

International Classification:

G01N 27/22
G01N 33/543
B01L 3/00
G16H 10/40
G16H 70/60
G16H 50/20

Abstract:

Embodiments herein relate to non-invasive bladder cancer detection systems and methods. In an embodiment, a method for detecting a disease state in a subject is included. The method includes obtaining a liquid biological sample from the subject and placing it into a container and contacting the liquid biological sample with a first chemical sensor element, where the first chemical sensor element can include a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of each of the discrete graphene varactors to obtain a first sample data set. Other embodiments are also included herein.

US Patent:

20210147238, May 20, 2021

Filed:

Nov 12, 2020

Appl. No.:

17/096104

Inventors:

- Minneapolis MN, US
- Maple Grove MN, US
Philippe Pierre Joseph Buhlmann - Minneapolis MN, US
Qun Su - Minneapolis MN, US
Justin Theodore Nelson - Minneapolis MN, US
Gregory J. Sherwood - North Oaks MN, US

International Classification:

C01B 32/19
C09D 5/00
C09D 9/00
C09D 127/12
G01N 33/00
G01N 27/22

Abstract:

Embodiments herein relate to methods and systems for applying a transfer material layer to graphene during a graphene fabrication process. In an embodiment, a method of producing a graphene sensor element is included. The method includes forming a graphene layer on a growth substrate and applying a fluoropolymer coating layer over the graphene layer. The method includes removing the growth substrate and transferring the graphene and fluoropolymer coating layers onto a transfer substrate, where the graphene layer is disposed on the transfer substrate and the fluoropolymer layer is disposed on the graphene layer. The method also includes removing the fluoropolymer coating layer. Other embodiments are also included herein.

US Patent:

20210148848, May 20, 2021

Filed:

Nov 23, 2020

Appl. No.:

17/101900

Inventors:

- Maple Grove MN, US
Gregory J. Sherwood - North Oaks MN, US
Justin Theodore Nelson - Minneapolis MN, US

International Classification:

G01N 27/22

Abstract:

Embodiments herein relate to systems and devices for measuring analyte presence on graphene varactors, which can be used for analyte sensing in physiological gas samples. In an embodiment, a system for measuring analyte presence on a graphene varactor is included having a capacitance to digital converter (CDC) and a graphene varactor. The CDC can be in electrical communication with the graphene varactor and can be configured to measure the capacitance of the graphene varactor in response to an excitation signal over a plurality of DC bias voltages. Other embodiments are also included herein.

US Patent:

20210072208, Mar 11, 2021

Filed:

Sep 4, 2020

Appl. No.:

17/012642

Inventors:

- Maple Grove MN, US
Justin Theodore Nelson - Minneapolis MN, US
Raia Colette Finc - Shoreview MN, US
Michael J. Lyden - Shoreview MN, US
John M. Darst - Oakdale MN, US
Michael Mathias Freking - Arden Hills MN, US

International Classification:

G01N 33/00
G01N 27/70
G01N 27/447

Abstract:

Embodiments herein relate to breath analysis system. In an embodiment, a gas measurement device is included having a housing defining an interior volume. The housing can include a fluid ingress port, a fluid egress port, a bottom wall, and a circuit board disposed within the interior volume. The circuit board can include a first side and a second side, where the first side of the circuit board faces inward toward the interior volume. The circuit board can include a plurality of gas sensors disposed on the first side of the circuit board and a plurality of conductive pads disposed on the second side of the circuit board, wherein a plurality of electrical contacts contact the conductive pads when the circuit board is seated within the housing. Other embodiments are also included herein.