Kai Yun Chen

US Patent:

8133472, Mar 13, 2012

Filed:

Apr 30, 2009

Appl. No.:

12/433258

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Kai Chen - Rockville MD, US
Joseph C. Walsh - Pacific Palisades CA, US
Qianwa Liang - Hacienda Heights CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 169, 424 111, 424 165, 424 91, 424 94, 424 944

Abstract:

Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

US Patent:

8293206, Oct 23, 2012

Filed:

Jun 1, 2009

Appl. No.:

12/455346

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Kai Chen - Rockville MD, US
Dhanalakshmi Kasi - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Gang Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61M 36/14
A61K 39/00

US Classification:

424 169, 4241811

Abstract:

The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.

US Patent:

8354092, Jan 15, 2013

Filed:

Aug 25, 2010

Appl. No.:

12/862955

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Rockville MD, US
Wei Zhang - Norwood MA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US
Peter J. H. Scott - Ypsilanti MI, US
Zhiyong Gao - Wynnewood PA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 249/00
C07D 343/00

US Classification:

424 153, 514359, 514449, 514461, 530330, 548255, 549429

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

8420052, Apr 16, 2013

Filed:

Jul 24, 2009

Appl. No.:

12/509259

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Kai Chen - Rockville MD, US
Anjana Sinha - San Diego CA, US
Eric Wang - San Diego CA, US
Gang Chen - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Henry Clifton Padgett - Hermosa Beach CA, US
Qianwa Liang - Hacienda Heights CA, US
Zhiyong Gao - Wynnewood PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 165, 424 181, 424 185

Abstract:

Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.

US Patent:

20110046378, Feb 24, 2011

Filed:

Feb 17, 2009

Appl. No.:

12/867502

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Qianwa Liang - Hacienda Heights CA, US
Brian A. Duclos - Kalamazoo MI, US
Wei Zhang - Los Angeles CA, US
Peter J.H. Scott - Ypsilanti MI, US
Kai Chen - Rockville MD, US
Zhiyong Gao - Wynnewood PA, US
Tieming Zhao - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Anjana Sinha - San Diego CA, US
Chunfang Xia - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US

Assignee:

SIEMENS MEDICAL SOLUTIONS USA, INC. - Malvern PA

International Classification:

C07D 471/04
C07D 235/10
C07D 311/30
C07D 209/88
C07D 311/16
C07D 217/24
C07D 261/08
C07D 217/04
C07D 215/38
C07D 405/04
C07D 215/233
C07D 407/04
C07D 249/06
C07D 401/04
C07D 209/80
C07D 405/12

US Classification:

546 86, 5483104, 549403, 549400, 548440, 549289, 546141, 548247, 546150, 546171, 5482664, 546153, 548255, 5462741, 548441, 548420, 548444, 546155

Abstract:

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease

US Patent:

20160367319, Dec 22, 2016

Filed:

Jun 18, 2015

Appl. No.:

14/743942

Inventors:

- San Leandro CA, US
Erik William Peterson - Walnut Creek CA, US
Kai Chen - Potomac MD, US
Cristhian Octavio Reyes - San Jose CA, US

International Classification:

A61B 18/24
A61F 9/008

Abstract:

A steerable laser probe including an optical fiber, a flexible tubular sleeve positioned co-axially with the flexible tubular sleeve relative to an axis, and a straightening sleeve positioned co-axially with the flexible tubular sleeve and the optical fiber relative to the axis, and positioned between the flexible tubular sleeve and the optical fiber along the axis.