Karel J. M. Brands - Jersey City NJ Karen M. Conrad - Union NJ John M. Williams - Belle Mead NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C07D20708
US Classification:
548537
Abstract:
Crystalline 2S-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]-amino]benzoic acid and salts and solvates thereof are disclosed. A crystalline type is described.
Process For The Synthesis Of (2R, 2-Alpha-R, 3A)-2-[1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethoxy]-3-(4-Fluorophenyl)-1, 4-Oxazine
Karel M. Jos Brands - Jersey City NJ Karen M. Conrad - Clark NJ Matthew M. Zhao - Edison NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C07D295027
US Classification:
544174, 544170
Abstract:
The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.