Karen W James

US Patent:

7056947, Jun 6, 2006

Filed:

Jun 24, 2003

Appl. No.:

10/603054

Inventors:

James C. Powers - Atlanta GA, US
Juliana L. Asgian - Fullerton CA, US
Karen E. James - Cumming GA, US

Assignee:

Georgia Tech Research Corp. - Atlanta GA

International Classification:

A61K 31/335
C07D 303/38

US Classification:

514475, 549548

Abstract:

The present invention provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide epoxide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition. Such treatable conditions include viral infections, stroke, neurodegenerative disease, and inflammatory disease, among others.

US Patent:

7482379, Jan 27, 2009

Filed:

Feb 18, 2005

Appl. No.:

11/062017

Inventors:

James C. Powers - Atlanta GA, US
Juliana Asgian - Fullerton CA, US
Özlem Dogan Ekici - Columbus OH, US
Marion Gabriele Gotz - Hirschau, DE
Karen Ellis James - Cumming GA, US
Zhao Zhao Li - Norcross GA, US
Brian Rukamp - Greenleaf WI, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

A61K 31/15
C07C 243/10

US Classification:

514614, 564151

Abstract:

The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.