Karen J Morrison

US Patent:

7494646, Feb 24, 2009

Filed:

Apr 23, 2004

Appl. No.:

10/830899

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Soudabeh Etessami - Tarzana CA, US
Pia M. Challita-Eid - Encino CA, US
Juan J. Perez-Villar - Los Angeles CA, US
Karen J. Morrison - Santa Monica CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Jean Gudas - Pacific Palisades CA, US
Arthur B. Raitano - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

A61K 48/00

US Classification:

4241301, 4241781, 435 71

Abstract:

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

US Patent:

7939503, May 10, 2011

Filed:

Jun 4, 2004

Appl. No.:

10/861662

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Soudabeh Etessami - Tarzana CA, US
Pia M. Challita-Eid - Encino CA, US
Juan J. Perez-Villar - Los Angeles CA, US
Karen J. Morrison - Santa Monica CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Jean Gudas - Pacific Palisades CA, US
Arthur B. Raitano - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

A61K 31/70

US Classification:

514 44

Abstract:

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

US Patent:

7947276, May 24, 2011

Filed:

Oct 19, 2006

Appl. No.:

11/584413

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Soudabeh Etessami - Tarzana CA, US
Pia M. Challita-Eid - Encino CA, US
Juan J. Perez-Villar - Los Angeles CA, US
Karen J. Morrison Morrison - Santa Monica CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Jean Gudas - Pacific Palisades CA, US
Arthur B. Raitano - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

A61K 39/00

US Classification:

4241781, 4241301

Abstract:

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

US Patent:

8008442, Aug 30, 2011

Filed:

Apr 22, 2004

Appl. No.:

11/587197

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Soudabeh Etessami - Tarzana CA, US
Pia M. Challita-Eid - Encino CA, US
Juan J. Perez-Villar - Los Angeles CA, US
Karen J. Morrison - Santa Monica CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Jean Gudas - Pacific Palisades CA, US
Arthur B. Raitano - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

C07K 16/00

US Classification:

5303871, 5303917, 4241781

Abstract:

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

US Patent:

8013135, Sep 6, 2011

Filed:

Dec 29, 2006

Appl. No.:

11/648757

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Soudabeh Etessami - Tarzana CA, US
Pia M. Challita-Eid - Encino CA, US
Juan J. Perez-Villar - Los Angeles CA, US
Karen J. Morrison - Santa Monica CA, US
Xiao-Chi Jia - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Jean Gudas - Pacific Palisades CA, US
Arthur B. Raitano - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

C07H 21/02

US Classification:

536 231, 536 243

Abstract:

Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

US Patent:

20030165505, Sep 4, 2003

Filed:

Jan 31, 2002

Appl. No.:

10/062109

Inventors:

Pia Challita-Eid - Encino CA, US
Arthur Raitano - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Rene Hubert - Los Angeles CA, US
Karen Morrison - Santa Monica CA, US
Aya Jakobovits - Beverly Hills CA, US

International Classification:

A61K039/395
C12P021/00
C12N005/06
C07K016/40
A61K048/00

US Classification:

424/146100, 800/006000, 530/388260, 435/338000, 514/044000

Abstract:

A protein obtainable from a non pathogenic microorganism, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined an expression vector comprising nucleic acid encoding such protein or peptide a recombinant microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and/or treatment of disease or illness associated with a mucosa colonising pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described.

US Patent:

20030191073, Oct 9, 2003

Filed:

Nov 7, 2001

Appl. No.:

10/005480

Inventors:

Pia Challita-Eid - Encino CA, US
Arthur Raitano - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Rene Hubert - Los Angeles CA, US
Karen Morrison - Santa Monica CA, US
Aya Jakobovits - Beverly Hills CA, US

International Classification:

A61K048/00
C12Q001/68
G01N033/574

US Classification:

514/044000, 424/093210, 435/006000, 435/007230

Abstract:

A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.

US Patent:

20030206905, Nov 6, 2003

Filed:

Nov 7, 2002

Appl. No.:

10/291241

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Arthur Raitano - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Rene Hubert - Los Angeles CA, US
Karen Morrison - Santa Monica CA, US
Robert Morrison - Santa Monica CA, US
Pia Challita-Eid - Encino CA, US

International Classification:

A61K039/395
C12P021/02
C12N005/06

US Classification:

424/145100, 800/006000, 435/326000, 530/388100

Abstract:

A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberranty expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.