Karen L Reue

US Patent:

20020152483, Oct 17, 2002

Filed:

Dec 19, 2001

Appl. No.:

10/028056

Inventors:

Karen Reue - Torrance CA, US
Miklos Peterfy - Los Angeles CA, US

Assignee:

The Regents of the University of California

International Classification:

A01K067/00
C12Q001/68
C12P019/34

US Classification:

800/009000, 435/006000, 435/091200

Abstract:

This invention pertains to the identification and isolation of a gene implicated in the fatty liver dystrophy (fld) phenotype. Mouse and human forms of the novel gene, designated herein as Lpin1/LPIN1 (mouse and human genes, respectively), are identified. This invention additionally provides methods of screening for agents that alter adipose tissue development. The methods involve contacting a cell containing a Lpin1 gene with a test agent; and detecting a change in the expression or activity of a Lpin1 gene product, where a difference in the expression or activity of Lpin1 in the contacted cell indicates that the agent alters or is likely to alter adipose tissue development. Also provided are methods of identifying Lpin1 mutations, and methods of mitigating symptoms of lipodystrophy, obesity, diabetes, atherosclerosis and related pathologies.

US Patent:

20210145833, May 20, 2021

Filed:

Apr 15, 2019

Appl. No.:

17/047522

Inventors:

- Oakland CA, US
Min Chai - Los Angeles CA, US
Karen Lynn Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US
Gay Miriam Crooks - Los Angeles CA, US
Stephanie Cochonneau de Barros - Los Angeles CA, US
Meisheng Jiang - Thousand Oaks CA, US

International Classification:

A61K 31/517
A61K 31/7056
A61K 31/155
A61K 31/436
A61P 17/14
A61K 9/00
A61K 9/06

Abstract:

Disclosed are methods improving or stimulating hair regeneration; treating, inhibiting, or reducing hair loss; improving or stimulating hair growth; treating, inhibiting, or reducing pigmentation loss; and/or improving or stimulating pigmentation production in a subject with one or more autophagy inducing agents.

US Patent:

20200069621, Mar 5, 2020

Filed:

Nov 4, 2019

Appl. No.:

16/673081

Inventors:

- Oakland CA, US
Xudong Fu - Los Angeles CA, US
Xiang Yin - Los Angeles CA, US
Mansoureh Eghbali - Los Angeles CA, US
Jingyuan Li - San Diego CA, US
Karen Lynn Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US

International Classification:

A61K 31/194
A61K 31/616
A61K 31/365
A61K 31/198

Abstract:

Disclosed herein are methods of preventing, inhibiting, reducing, or treating ischemia and reperfusion injury to tissues with glutarate compounds such as α-ketoglutarate.

US Patent:

20190201357, Jul 4, 2019

Filed:

Mar 9, 2019

Appl. No.:

16/297599

Inventors:

- Oakland CA, US
Xudong Fu - Los Angeles CA, US
Xiang Yin - Los Angeles CA, US
Mansoureh Eghbali - Los Angeles CA, US
Jingyuan Li - San Diego CA, US
Karen Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US

International Classification:

A61K 31/194
A61K 31/198
A61K 31/365
A61K 31/616

Abstract:

Disclosed herein are methods of preventing, inhibiting, reducing, or treating ischemia and reperfusion injury to tissues with glutarate compounds such as α-ketoglutarate.

US Patent:

20190192470, Jun 27, 2019

Filed:

Mar 9, 2019

Appl. No.:

16/297590

Inventors:

- Oakland CA, US
Randall M. Chin - Van Nuys CA, US
Simon Diep - Huntington Beach CA, US
Melody Y. Pai - Cupertino CA, US
Brett Eugene Lomenick - Los Angeles CA, US
Xudong Fu - Los Angeles CA, US
Karen Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US
Michael E. Jung - Los Angeles CA, US
Gang Deng - Los Angeles CA, US
Heejun Hwang - Los Angeles CA, US
Meisheng Jiang - Thousand Oaks CA, US

International Classification:

A61K 31/225
A61K 31/198
A61K 45/06
A61K 31/194

Abstract:

Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutarate compounds, such as α-ketoglutate, and/or one or more glutamate compounds, such as 2-hydroxypentanedioate, and compositions thereof.

US Patent:

20170333373, Nov 23, 2017

Filed:

Apr 30, 2017

Appl. No.:

15/582748

Inventors:

- Oakland CA, US
Xudong Fu - Los Angeles CA, US
Xiang Yin - Los Angeles CA, US
Mansoureh Eghbali - Los Angeles CA, US
Jingyuan Li - Los Angeles CA, US
Karen Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US

International Classification:

A61K 31/194
A61K 31/616
A61K 31/365

Abstract:

Disclosed herein are methods of preventing, inhibiting, reducing, or treating ischemia and reperfusion injury to tissues with glutarate compounds such as α-ketoglutarate.

US Patent:

20170128395, May 11, 2017

Filed:

Jun 29, 2015

Appl. No.:

15/319589

Inventors:

- Oakland CA, US
Randall M. Chin - Van Nuys CA, US
Xudong Fu - Los Angeles CA, US
Heejun Hwang - Los Angeles CA, US
Karen Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US
Meisheng Jiang - Los Angeles CA, US
Brett E. Lomenick - Los Angeles CA, US
Xiang Yin - Los Angeles CA, US
Mansoureh Eghbali - Los Angeles CA, US
Jingyuan Li - Los Angeles CA, US
Samuel Wheeler French - Los Angeles CA, US
Ronik Khachatoorian - Los Angeles CA, US

International Classification:

A61K 31/19

Abstract:

Disclosed herein are methods for (a) treating, inhibiting, or reducing aging of a subject, (b) treating, inhibiting, or reducing an age-related symptom or an age-related disease in a subject, and/or (c) increasing the lifespan of a subject which comprise administering to the subject one or more ketobutyrate compounds and compositions thereof.

US Patent:

20160354334, Dec 8, 2016

Filed:

Feb 11, 2015

Appl. No.:

15/114014

Inventors:

- Oakland CA, US
Randall Chin - Van Nuys CA, US
Simon Diep - Huntington Beach CA, US
Melody Y. Pai - Cupertino CA, US
Brett E. Lomenick - Los Angeles CA, US
Xudong Fu - Los Angeles CA, US
Karen Reue - Torrance CA, US
Laurent Vergnes - Los Angeles CA, US
Michael E. Jung - Los Angeles CA, US
Gang Deng - Los Angeles CA, US
Heejun Hwang - Los Angeles CA, US
Meisheng Jiang - Los Angeles CA, US

International Classification:

A61K 31/225
A61K 31/194

Abstract:

Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutamate compounds, such as α-ketoglutate, and/or one or more glutamate compounds, such as -hydroxypentanedioate, and compositions thereof.