Karl A Schmidt

US Patent:

20130336897, Dec 19, 2013

Filed:

Jun 18, 2013

Appl. No.:

13/920694

Inventors:

Gerald L. Wolf - Newton MA, US
Karl F. Schmidt - Watertown MA, US

International Classification:

A61K 49/18

US Classification:

424 936

Abstract:

Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in their lysosomes. The amount of USPIO loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal. Both fixed macrophages and activated macrophages associated with inflammatory diseases and cancer phagocytize USPIOs, and the loaded macrophages can serve to identify the extent of a macrophage-dependent disease as well as to direct treatment options. Furthermore, the absorption of energy from incident electromagnetic waves by the aggregated nanoparticles can be used for conformal thermotherapy. The USPIOs can further be used to carry drugs to the same activated macrophages. The co-administered drugs can be bound to the USPIO by condition-dependent releasing links that are responsive to local pH or heating.

US Patent:

20190200943, Jul 4, 2019

Filed:

Dec 21, 2018

Appl. No.:

16/229671

Inventors:

- Cambridge MA, US
Marisa J. Bober - Everett MA, US
Victoria Cabot - Somerville MA, US
Courtney D. Hilliard - Cambridge MA, US
Ara N. Knaian - Newton MA, US
Seth O. Newburg - Arlington MA, US
John William Hoppin - Boston MA, US
Karl F. Schmidt - Watertown MA, US

Assignee:

Biogen MA Inc. - Cambridge MA

International Classification:

A61B 6/00
A61B 5/00
A61B 6/03
A61B 6/04
A61B 5/0275

Abstract:

Various embodiments of medical detector systems as well as their methods of operation are disclosed. In one embodiment, one or more detectors are coupled to wearable structures for detecting at least a first tracer within a body portion. In another embodiment, one or more detectors are coupled to a wearable structure, where the detector corresponds to a CMOS chip that directly detects a first radioactive tracer.

US Patent:

20170086763, Mar 30, 2017

Filed:

Sep 23, 2016

Appl. No.:

15/275154

Inventors:

- Cambridge MA, US
Marisa J. Bober - Everett MA, US
Victoria Cabot - Somerville MA, US
Courtney D. Hilliard - Cambridge MA, US
Ara N. Knaian - Newton MA, US
Seth O. Newburg - Arlington MA, US
John William Hoppin - Boston MA, US
Karl F. Schmidt - Watertown MA, US

Assignee:

Biogen MA Inc. - Cambridge MA

International Classification:

A61B 6/00
A61B 5/00

Abstract:

Various embodiments of medical detector systems as well as their methods of operation are disclosed. In one embodiment, one or more detectors are coupled to wearable structures for detecting at least a first tracer within a body portion. In another embodiment, one or more detectors are coupled to a wearable structure, where the detector corresponds to a CMOS chip that directly detects a first radioactive tracer.

US Patent:

20140249413, Sep 4, 2014

Filed:

Mar 10, 2014

Appl. No.:

14/202044

Inventors:

Gerald L. Wolf - Newton MA, US
Karl F. Schmidt - Watertown MA, US

International Classification:

A61K 49/18
A61B 17/32

US Classification:

600439, 424 932, 600476

Abstract:

Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in their lysosomes. The amount of USPIO loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal. Both fixed macrophages and activated macrophages associated with inflammatory diseases and cancer phagocytize USPIOs, and the loaded macrophages can serve to identify the extent of a macrophage-dependent disease as well as to direct treatment options. Furthermore, the absorption of energy from incident electromagnetic waves by the aggregated nanoparticles can be used for conformal thermotherapy. The USPIOs can further be used to carry drugs to the same activated macrophages. The co-administered drugs can be bound to the USPIO by condition-dependent releasing links that are responsive to local pH or heating.