Karthikan Rajagopal

age ~52

from Irvine, CA

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Also known as:
  • Karthika Rajagopal
  • Karthikan Rajagobal
  • Rajagopal Karthikan
Related to:
Connected to:

Karthikan Rajagopal Phones & Addresses

  • Irvine, CA
  • 5203 Palazzo Dr, Dublin, CA 94568
  • Foster City, CA
  • Malvern, PA
  • Wilmington, DE
  • Dearborn, MI
  • Newark, DE

Us Patents

  • Novel Hydrogels And Uses Thereof

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  • US Patent:
    20110052692, Mar 3, 2011
  • Filed:
    Jul 30, 2010
  • Appl. No.:
    12/847476
  • Inventors:
    Bulent Ozbas - North Bergen NJ, US
    Juliana Kretsinger - Martinsville IN, US
    Lisa A. Butterick - Wilmington DE, US
    Karthikan Rajagopal - Wilmington DE, US
    Darrin J. Pochan - Landenberg PA, US
    Joel P. Schneider - Newark DE, US
  • Assignee:
    University of Delaware - Newark DE
  • International Classification:
    A61K 9/10
    C07K 7/08
    A61K 38/02
    A61K 35/12
    C12N 5/071
    G01N 33/00
    C07K 1/14
    A61P 17/02
  • US Classification:
    424484, 530326, 514 11, 424 937, 435325, 435366, 435326, 436 86, 530412, 5303871
  • Abstract:
    The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

  • Novel Hydorgels And Uses Thereof

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  • US Patent:
    20070128175, Jun 7, 2007
  • Filed:
    Nov 14, 2006
  • Appl. No.:
    11/598763
  • Inventors:
    Bulent Ozbas - North Bergen NJ, US
    Juliana Kretsinger - Martinsville IN, US
    Lisa Butterick - Wilmington DE, US
    Karthikan Rajagopal - Wilmington DE, US
    Darrin Pochan - Landenberg PA, US
    Joel Schneider - Newark DE, US
  • International Classification:
    A61K 35/12
    A61K 38/10
    G01N 33/53
    A61K 9/14
  • US Classification:
    424093700, 514013000, 424488000, 435007100
  • Abstract:
    The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

  • Optimized Antibody Compositions For Treatment Of Ocular Disorders

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  • US Patent:
    20210363231, Nov 25, 2021
  • Filed:
    Aug 3, 2021
  • Appl. No.:
    17/392943
  • Inventors:
    - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
    Patrick KOENIG - San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
  • International Classification:
    C07K 16/22
    A61K 47/61
    A61K 9/00
    A61K 9/06
    A61K 9/08
  • Abstract:
    The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).

  • Optimized Variants Of Anti-Vegf Antibodies

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  • US Patent:
    20210115124, Apr 22, 2021
  • Filed:
    Dec 21, 2020
  • Appl. No.:
    17/129251
  • Inventors:
    - South San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
    Amin FAMILI - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
  • International Classification:
    C07K 16/22
    A61K 47/60
    A61K 47/61
    A61K 39/395
    A61K 47/34
    C07K 14/475
    C07K 16/44
    C07K 16/46
    C12N 15/10
    C12N 15/115
  • Abstract:
    The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

  • Optimized Antibody Compositions For Treatment Of Ocular Disorders

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  • US Patent:
    20200002411, Jan 2, 2020
  • Filed:
    Sep 17, 2019
  • Appl. No.:
    16/572822
  • Inventors:
    - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
    Patrick KOENIG - San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
  • International Classification:
    C07K 16/22
    A61K 47/61
    A61K 9/00
    A61K 9/06
    A61K 9/08
  • Abstract:
    The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).

  • Optimized Variants Of Anti-Vegf Antibodies

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  • US Patent:
    20190100581, Apr 4, 2019
  • Filed:
    Jul 12, 2018
  • Appl. No.:
    16/033499
  • Inventors:
    - South San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
    Amin FAMILI - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
  • International Classification:
    C07K 16/22
    C07K 16/46
    A61K 47/61
    C12N 15/10
    C12N 15/115
    C07K 16/44
    A61K 47/34
    A61K 47/60
    C07K 14/475
    A61K 39/395
    A61K 39/00
  • Abstract:
    The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

  • Optimized Variants Of Anti-Vegf Antibodies

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  • US Patent:
    20190031750, Jan 31, 2019
  • Filed:
    Jul 12, 2018
  • Appl. No.:
    16/033353
  • Inventors:
    - South San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
    Amin FAMILI - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
  • International Classification:
    C07K 16/22
    A61K 47/60
    C07K 16/46
    A61K 47/61
    C12N 15/10
    A61K 39/395
    C12N 15/115
  • Abstract:
    The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

  • Optimized Variants Of Anti-Vegf Antibodies

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  • US Patent:
    20170096479, Apr 6, 2017
  • Filed:
    Sep 23, 2016
  • Appl. No.:
    15/274612
  • Inventors:
    - South San Francisco CA, US
    Chingwei Vivian LEE - Foster City CA, US
    Karthikan RAJAGOPAL - South San Francisco CA, US
    Amin FAMILI - South San Francisco CA, US
    Germaine FUH - Pacifica CA, US
  • International Classification:
    C07K 16/22
    C07K 16/46
    C12N 15/10
    C12N 15/115
    A61K 47/34
    C07K 16/44
    A61K 39/395
    C07K 14/475
  • Abstract:
    The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
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