Katherine Olivia Brown

US Patent:

20040142888, Jul 22, 2004

Filed:

Aug 7, 2003

Appl. No.:

10/638225

Inventors:

Veeraswamy Manne - Philadelphia PA, US
Mark Lynch - Madison CT, US
Petra Ross-MacDonald - Pennington NJ, US
Terry Stouch - West Windsor NJ, US
Naomi Laing - Stoneham MA, US
Pamela Carroll - Princeton NJ, US
Kevin Fitzgerald - Lambertville NJ, US
Louis Lombardo - Belle Mead NJ, US
Michael Costa - San Francisco CA, US
Mark Maxwell - San Francisco CA, US
Rachel Kindt - San Carlos CA, US
Mark Lackner - Brisbane CA, US
Tak Hung - Foster City CA, US
Carol O'Brian - Castro Valley CA, US
Hai Zhang - El Sobrante CA, US
Katherine Brown - San Francisco CA, US
Jae Lee - Cupertino CA, US

International Classification:

A61K048/00
G01N033/574
A61K031/5513
A61K031/47

US Classification:

514/044000, 514/221000, 514/310000, 435/007230

Abstract:

The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.

US Patent:

60425563, Mar 28, 2000

Filed:

Sep 4, 1998

Appl. No.:

9/148754

Inventors:

Kirk W. Beach - Seattle WA
Katherine G. Brown - Coppell TX
Melani I. Plett - Bellevue WA
Michael J. Caps - Seattle WA

Assignee:

University of Washington - Seattle WA

International Classification:

A61B 800

US Classification:

601 3

Abstract:

Phase of each transducer element of a high intensity focused (HIFU) transducer array is controlled to compensate for phase change introduced by varying velocity through differing tissue along a path towards a treatment volume. The echo of a specific harmonic of ultrasound pulses of moderate intensity and less than HIFU intensity are used to measure the propagation path transit time of each HIFU transducer element that will converge in a treatment volume through nonhomogeneous tissue. The moderate intensity is outside the linear region between molecular velocity fluctuations and pressure fluctuations. Thus, specific harmonic echoes are distributed in all directions from the treatment volume. Temporal delay in the specific harmonic echoes provide a measure of the propagation path transit time to transmit a pulse that will converge on the treatment volume.

US Patent:

58998616, May 4, 1999

Filed:

Oct 8, 1996

Appl. No.:

8/728280

Inventors:

Barry H. Friemel - Issaquah WA
Lee Weng - Bellevue WA
Katherine G. Brown - Issaquah WA

Assignee:

Siemens Medical Systems, Inc. - Iselin NJ

International Classification:

A61B 800

US Classification:

600443

Abstract:

A 3D field of view ultrasound image volume is derived from correlated frames of ultrasound image data. An operator manually translates an ultrasound probe across a patient target area. Frames of sensed echo signals are processed to detect probe motion using beam data registration and correlation techniques. Motion is detected by correlating the frames for probe translation among as many as 6 degrees of freedom. Image registration then is performed for correlated portions to accumulate a large ultrasound image. Such image encompasses an area larger than a single field of view image frame for the given manually-scanned transducer probe.

US Patent:

20200253746, Aug 13, 2020

Filed:

Jan 6, 2020

Appl. No.:

16/735384

Inventors:

- King of Prussia PA, US
Katherine Elizabeth Brown - Garnet Valley PA, US
James A. Sack - Elverson PA, US

International Classification:

A61F 2/46
A61F 2/44

Abstract:

An implant includes a body and a bone fixation system. The body includes an interior area disposed between a superior surface and an opposite inferior surface spaced from the superior surface in a vertical direction. In addition, the bone fixation system includes at least one blade disposed within the interior area of the body in an insertion position. Also, the bone fixation system further includes at least one strike plate engaging the at least one blade in the interior area of the body, the at least one strike plate being configured to move the at least one blade from the insertion position to an impaction position in which at least a portion of the blade protrudes past one of the superior surface and inferior surface of the body.

US Patent:

20190038433, Feb 7, 2019

Filed:

Jan 31, 2018

Appl. No.:

15/885230

Inventors:

- Wayne PA, US
Katherine Elizabeth Brown - Garnet Valley PA, US
James A. Sack - Elverson PA, US

International Classification:

A61F 2/46
A61F 2/44

Abstract:

An implant includes a body and a bone fixation system. The body includes an interior area disposed between a superior surface and an opposite inferior surface spaced from the superior surface in a vertical direction. In addition, the bone fixation system includes at least one blade disposed within the interior area of the body in an insertion position. Also, the bone fixation system further includes at least one strike plate engaging the at least one blade in the interior area of the body, the at least one strike plate being configured to move the at least one blade from the insertion position to an impaction position in which at least a portion of the blade protrudes past one of the superior surface and inferior surface of the body. Further, the at least one blade has a substantially U-shaped cross-sectional shape in a horizontal plane substantially perpendicular to the vertical direction.

US Patent:

20170281434, Oct 5, 2017

Filed:

Jun 15, 2017

Appl. No.:

15/623463

Inventors:

- Wayne PA, US
Katherine Elizabeth Brown - Garnet Valley PA, US
James A. Sack - Elverson PA, US

International Classification:

A61F 2/46
A61F 2/44
A61F 2/30

Abstract:

Implant fixation systems, kits and methods for interbody fusions are described herein. Preferably, the implant has a cage containing two deployable blades and one or more strike plates that are able to deploy the blades. The blades are positioned inside the cage such that one blade faces upward and the other blade faces downward. Protrusions on the ends of the blades fit into correspondingly shaped tracks on the interior surface of the cage, allowing movement of the blades inside the cage. The implant also has two wedge-shaped strike plates that fit into attachment regions located on the blades, which allow the strike plates to slide. Impaction of the strike plate(s) causes them to push the blades superiorly or inferiorly. In the impaction position, a portion of the blades protrudes beyond the superior and the inferior surfaces of the cage and fixes the cage in the adjacent vertebral bodies.

US Patent:

20160374831, Dec 29, 2016

Filed:

Jun 27, 2016

Appl. No.:

15/194323

Inventors:

- Wayne PA, US
Katherine Elizabeth Brown - Garnet Valley PA, US
James A. Sack - Elverson PA, US

International Classification:

A61F 2/46
A61F 2/44

Abstract:

Implant fixation systems, kits and methods for interbody fusions are described herein. Preferably, the implant has a cage containing two deployable blades and one or more strike plates that are able to deploy the blades. The blades are positioned inside the cage such that one blade faces upward and the other blade faces downward. Protrusions on the ends of the blades fit into correspondingly shaped tracks on the interior surface of the cage, allowing movement of the blades inside the cage. The implant also has two wedge-shaped strike plates that fit into attachment regions located on the blades, which allow the strike plates to slide. Impaction of the strike plate(s) causes them to push the blades superiorly or inferiorly. In the impaction position, a portion of the blades protrudes beyond the superior and the inferior surfaces of the cage and fixes the cage in the adjacent vertebral bodies.