Katherine Bro Brown

US Patent:

20040142888, Jul 22, 2004

Filed:

Aug 7, 2003

Appl. No.:

10/638225

Inventors:

Veeraswamy Manne - Philadelphia PA, US
Mark Lynch - Madison CT, US
Petra Ross-MacDonald - Pennington NJ, US
Terry Stouch - West Windsor NJ, US
Naomi Laing - Stoneham MA, US
Pamela Carroll - Princeton NJ, US
Kevin Fitzgerald - Lambertville NJ, US
Louis Lombardo - Belle Mead NJ, US
Michael Costa - San Francisco CA, US
Mark Maxwell - San Francisco CA, US
Rachel Kindt - San Carlos CA, US
Mark Lackner - Brisbane CA, US
Tak Hung - Foster City CA, US
Carol O'Brian - Castro Valley CA, US
Hai Zhang - El Sobrante CA, US
Katherine Brown - San Francisco CA, US
Jae Lee - Cupertino CA, US

International Classification:

A61K048/00
G01N033/574
A61K031/5513
A61K031/47

US Classification:

514/044000, 514/221000, 514/310000, 435/007230

Abstract:

The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein. The present invention further provides a 3-dimensional structure of RabGGT, and methods of use of the structure to identify compounds that modulate RabGGT activity.