Joe's American Bar and Grill Natick, MA Jan 2012 to Jun 2013 WaitressThe Eagle Club Framingham, MA 2009 to 2013 VOLUNTEERJ.J. McKay Restaurant Wayland, MA Apr 2010 to Feb 2011 WaitressLongfellow Sports Club Wayland, MA Nov 2007 to Jun 2010 Lifeguard
Education:
Lincoln Technical Institute Lowell, MA 2014 doctor in Medical Assistant Program
Skills:
CPR and First Aid Certified
Us Patents
Selective Histone Deacetylase (Hdac) Degraders And Methods Of Use Thereof
- Boston MA, US Yuan Xiong - Waltham MA, US Katherine Donovan - Brookline MA, US Nicholas Eleuteri - Braintree MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
A61K 47/55 A61K 47/54
Abstract:
The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by aberrant histone deacetylase (HCADC) (e.g., HDAC3) activity.
Selective Dual Histone Deacetylase 6/8 (Hdac6/8) Degraders And Methods Of Use Thereof
- Boston MA, US Yuan Xiong - Waltham MA, US Katherine Donovan - Brookline MA, US Nicholas Eleuteri - Braintree MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
A61K 47/55 A61K 47/54 A61K 47/60
Abstract:
The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by aberrant histone deacetylases 6 and 8 (HDAC6/8) activity.
Degradation Of Akt By Conjugation Of Atp-Competitive Akt Inhibitor Gdc-0068 With E3 Ligase Ligands And Methods Of Use
- Boston MA, US Tinghu Zhang - Brookline MA, US Eric Fischer - Chestnut Hill MA, US Katherine Donovan - Boston MA, US Emily Erickson - Brookline MA, US Alex Toker - Dedham MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA BETH ISRAEL DEACONESS MEDICAL CENTER, INC. - Boston MA
International Classification:
A61K 47/55 A61K 47/54 A61K 31/337 A61P 35/00
Abstract:
Disclosed are bifunctional compounds comprising a GDC-0068 analog that binds AKT isoforms AKT1, 2 and 3, pharmaceutical compositions, and methods for treating diseases or conditions mediated by dysfunctional AKT activity.
Degraders Of Kelch-Like Ech-Associated Protein 1 (Keap1)
- Boston MA, US Tinghu Zhang - Brookline MA, US Guangyan Du - Roslindale MA, US Nathaniel Henning - Brookline MA, US Jie Jiang - Brookline MA, US Eric Fischer - Chestnut Hill MA, US Katherine Donovan - Boston MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
C07D 419/04 C07D 401/14 C07D 401/04 A61K 47/54
Abstract:
The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by Kelch-like ECH-associated protein 1 (KEAP1). In some aspects, the present invention is directed to methods of treating diseases or disorders involving dysfunctional (e.g., dysregulated) KEAP1 activity, that entails administration of a therapeutically effective amount of a bifunctional compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof, to a subject in need thereof.
Selective Hdac6 Degraders And Methods Of Use Thereof
- Boston MA, US Yuan Xiong - Waltham MA, US Katherine Donovan - Brookline MA, US Nicholas Eleuteri - Braintree MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
A61K 47/54 A61K 47/55
Abstract:
The present invention relates to bispecific compounds, compositions, and methods for treating diseases or conditions mediated by aberrant histone deacety lase 6 (HDAC6) activity.
- Boston MA, US Tinghu Zhang - Brookline MA, US Eric Fischer - Chestnut Hill MA, US Alyssa Verano - Allston MA, US Zhixiang He - Brookline MA, US Guangyan Du - Jamaica Plain MA, US Katherine Donovan - Boston MA, US Radoslaw Nowak - Boston MA, US Jing Ting Christine Yuan - Brookline MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
C07D 495/14 A61K 47/54 A61K 47/55 A61P 35/00
Abstract:
Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.
- Boston MA, US Tinghu Zhang - Brookline MA, US Eric Fischer - Chestnut Hill MA, US Zhixiang He - Brookline MA, US Guangyan Du - Jamaica Plain MA, US Katherine Donovan - Boston MA, US Radoslaw Nowak - Boston MA, US Jing Ting Christine Yuan - Brookline MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
C07D 473/16 C07D 405/14 C07D 473/34 A61P 35/00
Abstract:
Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.
- Boston MA, US Tinghu Zhang - Brookline MA, US Eric Fischer - Chestnut Hill MA, US Alyssa Verano - Allston MA, US Zhixiang He - Brookline MA, US Guangyan Du - Jamaica Plain MA, US Katherine Donovan - Boston MA, US Radoslaw Nowak - Boston MA, US Jing Ting Christine Yuan - Brookline MA, US Hu Liu - Newton MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
C07D 401/12
Abstract:
Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.
El Centro School South Pasadena CA 1964-1965, Las Flores Elementary School South Pasadena CA 1965-1967, Marengo Elementary School South Pasadena CA 1967-1968, McKinley Elementary School San Gabriel CA 1969-1971, Jefferson Middle School San Gabriel CA 1971-1973, Capistrano Community Education School San Juan Capistrano CA 1976-1976, Ortega High School Lake Elsinore CA 1976-1977
Community:
Lynne Beckett, Jenny Celli
Biography:
Well....where to start...LOL
I always wanted to be a marine biologist when I grew ...