Katherine E Donovan

US Patent:

20220226481, Jul 21, 2022

Filed:

Apr 8, 2020

Appl. No.:

17/601640

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Katherine Donovan - Boston MA, US
Emily Erickson - Brookline MA, US
Alex Toker - Dedham MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. - Boston MA

International Classification:

A61K 47/55
A61K 47/54
A61K 31/337
A61P 35/00

Abstract:

Disclosed are bifunctional compounds comprising a GDC-0068 analog that binds AKT isoforms AKT1, 2 and 3, pharmaceutical compositions, and methods for treating diseases or conditions mediated by dysfunctional AKT activity.

US Patent:

20220177466, Jun 9, 2022

Filed:

Apr 7, 2020

Appl. No.:

17/601536

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Guangyan Du - Roslindale MA, US
Nathaniel Henning - Brookline MA, US
Jie Jiang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Katherine Donovan - Boston MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 419/04
C07D 401/14
C07D 401/04
A61K 47/54

Abstract:

The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions mediated by Kelch-like ECH-associated protein 1 (KEAP1). In some aspects, the present invention is directed to methods of treating diseases or disorders involving dysfunctional (e.g., dysregulated) KEAP1 activity, that entails administration of a therapeutically effective amount of a bifunctional compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof, to a subject in need thereof.

US Patent:

20210300941, Sep 30, 2021

Filed:

Jun 27, 2019

Appl. No.:

17/255772

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Alyssa Verano - Allston MA, US
Zhixiang He - Brookline MA, US
Guangyan Du - Jamaica Plain MA, US
Katherine Donovan - Boston MA, US
Radoslaw Nowak - Boston MA, US
Jing Ting Christine Yuan - Brookline MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 495/14
A61K 47/54
A61K 47/55
A61P 35/00

Abstract:

Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

US Patent:

20210292325, Sep 23, 2021

Filed:

Jun 27, 2019

Appl. No.:

17/255734

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Zhixiang He - Brookline MA, US
Guangyan Du - Jamaica Plain MA, US
Katherine Donovan - Boston MA, US
Radoslaw Nowak - Boston MA, US
Jing Ting Christine Yuan - Brookline MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 473/16
C07D 405/14
C07D 473/34
A61P 35/00

Abstract:

Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.

US Patent:

20210284624, Sep 16, 2021

Filed:

Jun 27, 2019

Appl. No.:

17/255738

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Alyssa Verano - Allston MA, US
Zhixiang He - Brookline MA, US
Guangyan Du - Jamaica Plain MA, US
Katherine Donovan - Boston MA, US
Radoslaw Nowak - Boston MA, US
Jing Ting Christine Yuan - Brookline MA, US
Hu Liu - Newton MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 401/12

Abstract:

Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

US Patent:

20210276996, Sep 9, 2021

Filed:

Jul 18, 2019

Appl. No.:

17/258340

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Guangyan Du - Jamaica Plain MA, US
Nozhat Safaee - Brookline MA, US
Nathaniel Henning - Brookline MA, US
Katherine Donovan - Boston MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 419/14
C07D 495/14
C07D 403/12

Abstract:

Disclosed are bifunctional compounds, pharmaceutical compositions containing them, and methods of making and using them to treat diseases and disorders characterized by aberrant protein activity wherein the protein is targeted for degradation by KEAP1 and the Cul3-based E3-ubiquitin ligase complex.

US Patent:

20210277018, Sep 9, 2021

Filed:

Jun 27, 2019

Appl. No.:

17/255750

Inventors:

- Boston MA, US
Tinghu Zhang - Brookline MA, US
Eric Fischer - Chestnut Hill MA, US
Alyssa Verano - Allston MA, US
Zhixiang He - Brookline MA, US
Guangyan Du - Jamaica Plain MA, US
Katherine Donovan - Boston MA, US
Radoslaw Nowak - Boston MA, US
Jing Ting Christine Yuan - Brookline MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 495/14
A61K 47/54

Abstract:

Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by dysregulated or dysfunctional protein activity that can be targeted by cereblon.

US Patent:

20210038599, Feb 11, 2021

Filed:

Apr 30, 2019

Appl. No.:

17/042634

Inventors:

- Boston MA, US
Nathanael Gray - Boston MA, US
Radoslaw Nowak - Boston MA, US
Katherine Donovan - Boston MA, US
Tinghu Zhang - Brookline MA, US
Yao Liu - Brookline MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

A61K 31/501

Abstract:

The present invention relates to compounds, compositions and methods for treating diseases or conditions mediated by proteins of the SWI/SNF chromatin-remodeling complex, including PB1.