Kathleen A Fischer

US Patent:

20210401735, Dec 30, 2021

Filed:

Sep 7, 2021

Appl. No.:

17/468558

Inventors:

- Emeryville CA, US
Kathleen E. Fischer - Emeryville CA, US
Tomoyuki Yoshie - Emeryville CA, US
Wouter Roorda - Emeryville CA, US

Assignee:

NANO PRECISION MEDICAL, INC. - Emeryville CA

International Classification:

A61K 9/00
A61K 38/26
A61K 9/48

Abstract:

Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

US Patent:

20200139099, May 7, 2020

Filed:

Jan 6, 2020

Appl. No.:

16/735130

Inventors:

- Emeryville CA, US
William G.M. Fischer - Emeryville CA, US
Kathleen Fischer - Emeryville CA, US
Adam D. Mendelsohn - Emeryville CA, US
Adam Monkowski - Emeryville CA, US

Assignee:

Nano Precision Medical, Inc. - Emeryville CA

International Classification:

A61M 39/02
A61M 37/00

Abstract:

The invention pertains to apparatuses, means and methods to promote uptake of fluids into a reservoir of an implantable drug delivery system though a porous membrane. Embodiments of the invention promote fluid uptake by creating a pressure differential between the reservoir of the drug delivery device and the environment of the device after implantation, for instance a subcutaneous pocket.

US Patent:

20200040140, Feb 6, 2020

Filed:

Oct 11, 2019

Appl. No.:

16/600249

Inventors:

- Emeryville CA, US
Au Duong - Emeryville CA, US
Kathleen Fischer - Emeryville CA, US
Wouter Roorda - Emeryville CA, US

Assignee:

NANO PRECISION MEDICAL, INC. - Emeryville CA

International Classification:

C08G 83/00
A61K 38/26
A61K 9/00
A61K 31/541
A61K 47/60

Abstract:

The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.

US Patent:

20190091140, Mar 28, 2019

Filed:

Nov 29, 2018

Appl. No.:

16/204890

Inventors:

- Emeryville CA, US
Kathleen E Fischer - Emeryville CA, US
Tomoyuki Yoshie - Emeryville CA, US
Wouter E. Roorda - Emeryville CA, US

Assignee:

Nano Precision Medical, Inc. - Emeryville CA

International Classification:

A61K 9/00
A61K 38/26
A61K 9/48

Abstract:

Embodiments of the invention include devices, compositions and methods for the controlled release of therapeutic substances, such as drugs. Control over the rate of release of the therapeutic substances from the devices is achieved by the use of nanoporous membranes in which the pore size is matched to the molecular diameter of the therapeutic substances. Some embodiments of the invention achieve zero-order release by the use of membranes with a pore diameter that is more than five times the Stokes' diameter of the therapeutic substance released.

US Patent:

20170274089, Sep 28, 2017

Filed:

Sep 4, 2015

Appl. No.:

15/508572

Inventors:

- Emeryville CA, US
Au DUONG - Emeryville CA, US
Kathleen FISCHER - Emeryville CA, US
Wouter ROORDA - Emeryville CA, US

International Classification:

A61K 47/48
A61K 38/26
C08G 83/00
A61K 9/00
C08L 89/00

Abstract:

The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.

US Patent:

20170000731, Jan 5, 2017

Filed:

Jan 23, 2015

Appl. No.:

15/113165

Inventors:

- Emeryville CA, US
Kathleen Fischer - Emeryville CA, US
Tomoyuki Yoshie - Emeryville CA, US

International Classification:

A61K 9/00
A61M 31/00

Abstract:

The present invention provides a method for controlling the internal diameter of nanopores to afford nanopore membranes with a zero-order rate of release of a therapeutic agent.

US Patent:

20140371687, Dec 18, 2014

Filed:

Dec 5, 2012

Appl. No.:

14/362554

Inventors:

- Emeryville CA, US
Kathleen E. Fischer - Oakland CA, US
Lily H. Peng - San Francisco CA, US
William G. Fischer - Oakland CA, US

International Classification:

A61M 31/00
A61K 38/21
C25D 5/50
A61K 9/48
C25D 11/34
C25D 5/48

US Classification:

604286, 205223, 205 50

Abstract:

The present invention provides a device including a titania nanotube membrane having a plurality of titania nanotubes on a titanium substrate where the titania nanotubes are open at both ends and capable of allowing diffusion of liquids or solids from one side of the membrane to the other through the titania nanotubes. Methods of making the titania nanotube membrane are also provided.