Kathryn C Elliott

US Patent:

6440681, Aug 27, 2002

Filed:

Jun 7, 1995

Appl. No.:

08/487596

Inventors:

Kathryn J. Elliott - San Diego CA
Steven B. Ellis - San Diego CA
Michael M. Harpold - El Cajon CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12N 1500

US Classification:

435 72, 435 691, 4352523, 4353201, 435325, 435 701, 435 711, 536 235

Abstract:

Methods for identifying compounds which modulate the activity of human neuronal nicotinic acetylcholine receptors are provided. Invention methods employ DNAs encoding alpha and beta subunits of human neuronal nicotinic acetylcholine receptors, and the polypeptides encoded thereby. Test cells useful for conducting invention assays include mammalian and amphibian cells containing said DNA. Various combinations of subunits (i. e. , one or more , , , , and subunits in combination with , and/or subunits) can be employed for the invention assays.

US Patent:

6485967, Nov 26, 2002

Filed:

Jun 7, 1995

Appl. No.:

08/484722

Inventors:

Kathryn J. Elliott - San Diego CA
Michael M. Harpold - El Cajon CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12N 510

US Classification:

435325, 536 235

Abstract:

DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i. e. , isolated or substantially pure) alpha subunits (specifically ) and beta subunits (specifically ) are provided. In addition, combinations of a plurality of subunits (i. e. , one or more of as , , , , , and/or subunits in combination with one or more of subunits are provided.

US Patent:

6524789, Feb 25, 2003

Filed:

Jun 7, 1996

Appl. No.:

08/660451

Inventors:

Kathryn J. Elliott - San Diego CA
Michael M. Harpold - El Cajon CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12Q 168

US Classification:

435 6, 435325, 514 44, 536 235, 536 241

Abstract:

Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding subunits and molecules encoding subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of , , , , , and/or subunits in combination with one or more of subunits or such as one or more of , and/or subunits in combination with an subunit are provided.

US Patent:

6664375, Dec 16, 2003

Filed:

Jun 27, 2001

Appl. No.:

09/892985

Inventors:

Kathryn J. Elliott - San Diego CA 92117
Steven B. Ellis - San Diego CA 92129
Michael M. Harpold - El Cajon CA 92021

International Classification:

C07K 14705

US Classification:

530350, 514 12, 435 691

Abstract:

DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing and subunits and isolated or substantially pure , and subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.

US Patent:

6936457, Aug 30, 2005

Filed:

Nov 1, 2000

Appl. No.:

09/703951

Inventors:

Allison Gillespie - San Diego CA, US
Brian O. Claeps - San Diego CA, US
Laura Elena Chavez-Noriega - San Diego CA, US
Robert Siegel - San Diego CA, US
Kathryn J. Elliott - San Diego CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12N001/20

US Classification:

4352523, 435 691, 4353201, 435352, 530350, 536 235

Abstract:

Isolated nucleic acid molecules, i. e. , DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing α and β subunits and recombinant (i. e. , isolated or substantially pure) α subunits and β subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i. e. , α, αααααand/or αin combination with at least one of an α and β subunit are also provided. A recombinant, non-human cell line expressing the human αsubunit of nAChR is disclosed.

US Patent:

7119067, Oct 10, 2006

Filed:

Jan 23, 2003

Appl. No.:

10/349836

Inventors:

Kathryn J. Elliott - San Diego CA, US
Michael M. Harpold - El Cajon CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07K 14/705

US Classification:

514 12, 530350

Abstract:

Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding αsubunits and molecules encoding βsubunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of α, α, α, α, α, αand/or αsubunits in combination with one or more of βsubunits or such as one or more of β, βand/or βsubunits in combination with an αsubunit are provided.

US Patent:

7169895, Jan 30, 2007

Filed:

Nov 25, 2002

Appl. No.:

10/303198

Inventors:

Kathryn J. Elliott - San Diego CA, US
Michael M. Harpold - El Cajon CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07K 14/435

US Classification:

530350

Abstract:

DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i. e. , isolated or substantially pure) alpha subunits (specifically α) and beta subunits (specifically β) are provided. In addition, combinations of a plurality of subunits (i. e. , one or more of α, α, α, α, α, αand/or αsubunits in combination with one or more of βsubunits are provided.

US Patent:

8617487, Dec 31, 2013

Filed:

Mar 25, 2009

Appl. No.:

12/383535

Inventors:

James Plante - La Jolla CA, US
David Becker - San Diego CA, US
Edgar MacBean - San Diego CA, US
Kathryn J. Elliott - San Diego CA, US

Assignee:

Venture lending & Leasing VI, Inc. - Portola Valley CA

International Classification:

B01L 3/00

US Classification:

422430, 422 50, 422501, 422502, 422503, 422536, 436180

Abstract:

Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.