2011 to 2000 Executive Assistant / Office AdministratorThe Chandler Law Group Staunton, VA 2008 to 2011 Legal Assistant / ParalegalHomemakerWaynesboro, VA 2005 to 2008Lee Technologies Fairfax, VA 2003 to 2005 Administrative Assistant II/ Sales Support & Office Assistant/AdministratorTeleperformance USA Beloit, WI 1998 to 2003 Administrative Assistant / Licensing Coordinator
Education:
Blue Ridge Community College Weyers Cave, VA 2010 to 2011 Legal Studies/Business Administration & ManagementSouth University Savannah, GA 2009 to 2010Cardinal Stritch University Beloit, WI 2000 to 2001 Diploma in General StudiesBeloit Memorial High School Beloit, WI 1996
Jeffrey A. Moscow - Silver Spring MD Kenneth H. Cowan - Potama MD Kathy Dixon - Olney MD Rui He - Germantown MD
Assignee:
The United States of America as represented by the Department of Health & Human Services - Washington DC
International Classification:
C12Q 168 C12P 2100 C12N 1509 C12N 1512
US Classification:
435 691
Abstract:
One shortcoming of methotrexate chemotherapy is that previously responsive tumors can become refractory to methotrexate after continued exposure. Such methotrexate resistance may be due to underexpression of reduced folate carrier (RFC) protein. The present invention provides DNA molecules encoding human RFC. The present invention also relates to expression vectors comprising RFC-encoding DNA molecules, and to the use of such vectors to restore methotrexate sensitivity in mammalian cells. The present invention further relates to antibodies that bind with human RFC protein, and to methods of detecting human RFC protein using such antibodies.
Antibodies To Human Reduced Folate Carrier Protein
Jeffrey A. Moscow - Silver Spring MD Kenneth H. Cowan - Potoma MD Kathy Dixon - Olney MD Rui He - Germantown MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07K 1600 G01N 3353 G01N 33567 G01N 33573
US Classification:
435 71
Abstract:
One shortcoming of methotrexate chemotherapy is that previously responsive tumors can become refractory to methotrexate after continued exposure. Such methotrexate resistance may be due to underexpression of reduced folate carrier (RFC) protein. The present invention provides DNA molecules encoding human RFC. The present invention also relates to expression vectors comprising RFC-encoding DNA molecules, and to the use of such vectors to restore methotrexate sensitivity in mammalian cells. The present invention further relates to antibodies that bind with human RFC protein, and to methods of detecting human RFC protein using such antibodies.
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