Kavitha Yaddanapudi

US Patent:

20150183834, Jul 2, 2015

Filed:

Apr 30, 2014

Appl. No.:

14/266355

Inventors:

- New York NY, US
Kavitha YADDANAPUDI - Union City NJ, US
Gustavo PALACIOS - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07K 14/005
G01N 33/50
C12N 7/00

Abstract:

The invention provides a region of strong secondary structure conservation between the C-terminus domain of the envelope glycoprotein of filoviruses and an immunosuppressive domain found in retroviral envelope glycoproteins. The invention provides filoviral peptides and modified derivatives thereof with strong immunosuppressive bioactivity. The invention further provides methods for treatment of autoimmune disorders by administering the immunosuppressive peptide. The invention also provides methods for the identification of therapeutic agents that modulate the immunosuppressive activity of the peptides. Antibodies against the inventive peptides and the modified derivatives thereof are also provided. Furthermore, the invention provides methods for treatment of filoviral infection by administering compositions comprising the antibodies and/or the therapeutic agents that modulate the immunosuppressive activity of the inventive peptides.