Kay M Tye

US Patent:

20130295015, Nov 7, 2013

Filed:

Nov 4, 2011

Appl. No.:

13/882719

Inventors:

Karl Deisseroth - Stanford CA, US
Kay Tye - Cambridge MA, US
Lief Fenno - San Francisco CA, US

Assignee:

The Board of Trustees of Leland Stanford Jnior Universtiy - Palo Alto CA

International Classification:

A61K 49/00

US Classification:

424 92, 800 9, 4353201, 514 44 R, 435325

Abstract:

Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.

US Patent:

20180333456, Nov 22, 2018

Filed:

Apr 19, 2018

Appl. No.:

15/957608

Inventors:

- Stanford CA, US
Kay Tye - Cambridge MA, US
Lief Fenno - San Francisco CA, US

International Classification:

A61K 38/17
A01K 67/027
G01N 33/50
A61K 9/00
A61K 49/00
C07K 14/705
A61K 41/00
C12N 15/85
C12N 15/86
C12N 7/00
A61K 48/00
A61N 5/06
A61B 5/16

Abstract:

Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.

US Patent:

20160303192, Oct 20, 2016

Filed:

Jun 27, 2016

Appl. No.:

15/194379

Inventors:

- Stanford CA, US
Kay Tye - Cambridge MA, US
Lief Fenno - San Francisco CA, US

International Classification:

A61K 38/17
A61K 48/00
C12N 7/00
A61K 49/00
A61B 5/16
A01K 67/027
C12N 15/85
C12N 15/86
G01N 33/50
A61N 5/06
C07K 14/705
A61K 9/00

Abstract:

Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.

US Patent:

20150174244, Jun 25, 2015

Filed:

Nov 26, 2014

Appl. No.:

14/555048

Inventors:

- PALO ALTO CA, US
Kay Tye - Cambridge MA, US
Lief Fenno - San Francisco CA, US

International Classification:

A61K 41/00
A61N 5/06
A61B 5/16
A61K 38/17

Abstract:

Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.

US Patent:

20150040249, Feb 5, 2015

Filed:

Mar 13, 2013

Appl. No.:

14/385331

Inventors:

- Palo alto CA, US
Kay M. Tye - Cambridge MA, US
Melissa R. Warden - San Mateo CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 49/00
C12N 15/85
A01K 67/027

US Classification:

800 3, 800 9

Abstract:

The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light-responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.