Keith Edward Allen

US Patent:

6762342, Jul 13, 2004

Filed:

Jul 6, 2001

Appl. No.:

09/900708

Inventors:

Keith D. Allen - Cary NC

Assignee:

Deltagen, Inc. - San Carlos CA

International Classification:

A01K 67027

US Classification:

800 18, 800 3, 800 22, 435325

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an intestinal alkaline phosphatase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

US Patent:

6765126, Jul 20, 2004

Filed:

Jul 6, 2001

Appl. No.:

09/900497

Inventors:

Keith D. Allen - Cary NC

Assignee:

Deltagen Inc. - San Carlos CA

International Classification:

G01N 3300

US Classification:

800 18, 800 3, 800 25

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a NPY6 receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

US Patent:

6784335, Aug 31, 2004

Filed:

Jun 29, 2001

Appl. No.:

09/897772

Inventors:

Keith D. Allen - Cary NC

Assignee:

Deltagen, Inc. - San Carlos CA

International Classification:

A01K 67027

US Classification:

800 18, 800 21, 800 25, 435325

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a BMP gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

US Patent:

6858772, Feb 22, 2005

Filed:

Oct 5, 2001

Appl. No.:

09/972741

Inventors:

Keith D. Allen - Cary NC, US

Assignee:

Deltagen, Inc. - San Carlos CA

International Classification:

A01K067/027
C12N015/00

US Classification:

800 18, 800 25

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in the magnesium-dependent protein phosphatase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

US Patent:

6909031, Jun 21, 2005

Filed:

Dec 5, 2001

Appl. No.:

10/010065

Inventors:

Keith D. Allen - Cary NC, US
Mark Moore - Redwood City CA, US
William Matthews - Woodside CA, US

Assignee:

Deltagen, Inc. - Redwood City CA

International Classification:

A01K067/027
C12N015/00
C12N005/00
C12N005/02
C12N005/06

US Classification:

800 18, 800 21, 800 25, 435325, 435354

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a glucagon receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions. The present invention also relates to diabetes and diabetic condition, as it demonstrates the role of the glucagon receptor in diabetes and diabetic conditions. The present invention further relates to weight gain and weight related conditions, such as obesity, and demonstrates the role of the glucagon receptor in weight gain and weight related conditions, such as obesity. In accordance with these aspects, the present invention provides methods and compositions useful in identifying, testing, and providing treatments for diabetes and diabetic conditions, weight gain and weight related conditions such as obesity.

US Patent:

6943277, Sep 13, 2005

Filed:

Jul 11, 2001

Appl. No.:

09/904180

Inventors:

Keith D. Allen - Cary NC, US

Assignee:

Deltagen, Inc. - San Carlos CA

International Classification:

G01N033/00
A01K067/00
A01K067/027
C12N015/00

US Classification:

800 3, 800 8, 800 18, 800 21

Abstract:

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a stefin homolog gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

US Patent:

7030291, Apr 18, 2006

Filed:

Jun 24, 2002

Appl. No.:

10/179410

Inventors:

Keith D. Allen - Cary NC, US

Assignee:

Deltagen, Inc. - San Carlos CA

International Classification:

A01K 67/027
C12N 15/00
C12N 5/00
C12N 5/02
C12N 5/06
C12N 5/10

US Classification:

800 18, 800 21, 800 14, 435325, 435354

Abstract:

The present invention relates to compositions and methods relating to the characterization and function of CYT28. Specifically, the present invention provides transgenic animals comprising disruptions in a CYT28 gene and methods of treating diseases conditions, such as pain. The present invention further relates to agents that modulate CYT28 and methods of screening for agents that modulate CYT28 for the treatment of diseases and conditions such as pain.

US Patent:

8131473, Mar 6, 2012

Filed:

May 20, 2005

Appl. No.:

11/133953

Inventors:

Marie Coffin - Cary NC, US
Keith D. Allen - Cary NC, US
Brian R. Bullard - Las Cruces NM, US
Alan J. Higgins - Chapel Hill NC, US

Assignee:

Metabolon, Inc. - Durham NC

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

The present invention provides data analysis methods for the rapid location of subsets of large, multivariable biological datasets that are of most interest for further analysis, for the investigation of molecular modes of action of biological phenomena of interest, and for the identification of sets of data points that best distinguish between experimental groups in larger datasets as putative biomarkers. While existing methods for analyzing large biological datasets generally provide too much information to the user, or not enough, the methods of the present invention entail taking user input on what kinds of trends are of interest and then finding results that match the designated trend. In such manner, the methods of the invention allow a user to quickly pinpoint the subset of data of most interest without a concomitant loss of a large percentage of relevant information, as is typical with standard methods. The methods of the invention allow for identification of molecular entities that are involved in a biological phenomenon of interest, entities that may have otherwise gone undiscovered in a large, multivariable dataset.