Keith D Hall

US Patent:

20160201055, Jul 14, 2016

Filed:

Jan 22, 2014

Appl. No.:

14/761442

Inventors:

- Detroit MI, US
Zhenggang Zhang - Troy MI, US
Michael Chopp - Southfield MI, US
Lei Wang - Troy MI, US
Douglas A. Hamilton - Emerald Hills CA, US
James W. Bennett - Emerald Hills CA, US
Keith Hall - Emerald Hills CA, US

International Classification:

C12N 15/113
A61K 38/22

Abstract:

Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings.