John K. Pratt - Kenosha WI, US David A. Betebenner - Libertyville IL, US Pamela L. Donner - Mundelein IL, US Brian E. Green - Wonder Lake IL, US Dale J. Kempf - Libertyville IL, US Keith F. McDaniel - Wauconda IL, US Clarence J. Maring - Palatine IL, US Vincent S. Stoll - Libertyville IL, US Rong Zhang - Skokie IL, US Hui-Ju Chen - Grayslake IL, US William J. Flosi - Evanston IL, US Larry L. Klein - Lake Forest IL, US Allan C. Krueger - Gurnee IL, US Dachun Liu - Waukegan IL, US Darold L. Madigan - Elk Grove Village IL, US Laura M. Maymon - Chicago IL, US Todd W. Rockway - Grayslake IL, US Kent D. Stewart - Gurnee IL, US Ming C. Yeung - Grayslake IL, US Qinghua Xie - Libertyville IL, US
John Pratt - Kenosha WI, US David Betebenner - Libertyville IL, US Pemela Donner - Mundelein IL, US Brian Green - Wonder Lake IL, US Dale Kempf - Libertyville IL, US Keith McDaniel - Wauconda IL, US Clarence Maring - Palatine IL, US Vincent Stoll - Libertyville IL, US Rong Zhang - Skokie IL, US
International Classification:
A61K031/549 C07D498/02 C07D285/16
US Classification:
514/222800, 514/223200, 544/010000, 544/012000
Abstract:
Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
John Pratt - Kenosha WI, US David Betebenner - Libertyville IL, US Pamela Donner - Mundelein IL, US Brian Green - Wonder Lake IL, US Dale Kempf - Libertyville IL, US Keith McDaniel - Wauconda IL, US Clarence Maring - Palatine IL, US Vincent Stoll - Libertyville IL, US Rong Zhang - Skokie IL, US
Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
John Pratt - Kenosha WI, US David Betebenner - Libertyville IL, US Pamela Donner - Mundelein IL, US Brian Green - Wonder Lake IL, US Dale Kempf - Libertyville IL, US Keith McDaniel - Wauconda IL, US Clarence Maring - Palatine IL, US Vincent Stoll - Libertyville IL, US Rong Zhang - Skokie IL, US
International Classification:
A61K031/549 C07D285/22
US Classification:
514/223200, 544/009000, 544/012000
Abstract:
Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
John Pratt - Kenosha WI, US David Betebenner - Libertyville IL, US Pamela Donner - Mundelin IL, US Brian Green - Wonder Lake IL, US Dale Kempf - Libertyville IL, US Keith McDaniel - Wauconda IL, US Clarence Maring - Palatine IL, US Vincent Stoll - Libertyville IL, US Rong Zhang - Skokie IL, US
International Classification:
C07D285/26 C07D285/22 A61K031/549
US Classification:
514223200, 544013000
Abstract:
The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
- North Chicago IL, US John K. Pratt - Kenosha WI, US Keith F. McDaniel - Wauconda IL, US Yujia Dai - Gurnee IL, US Steven D. Fidanze - Grayslake IL, US Lisa Hasvold - Grayslake IL, US James H. Holms - Gurnee IL, US Warren M. Kati - Gurnee IL, US Dachun Liu - Vernon Hills IL, US Robert A. Mantei - Franklin WI, US William J. McClellan - Waukegan IL, US George S. Sheppard - Wilmette IL, US Carol K. Wada - Evanston IL, US
The present invention provides for compounds of formula (I)wherein A, A, A, A, X, X, Y, L, G, R, and Rhave any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
- North Chicago IL, US John K. Pratt - Kenosha WI, US Keith F. McDaniel - Wauconda IL, US Yujia Dai - Gurnee IL, US Steven D. Fidanze - Grayslake IL, US Lisa Hasvold - Grayslake IL, US James H. Holms - Gurnee IL, US Warren M. Kati - Gurnee IL, US Dachun Liu - Vernon Hills IL, US Robert A. Mantei - Franklin WI, US William J. McClellan - Waukegan IL, US George S. Sheppard - Wilmette IL, US Carol K. Wada - Evanston IL, US
The present invention provides for compounds of formula (I)wherein A, A, A, A, X, X, Y, L, G, R, and Rhave any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
- North Chicago IL, US John Pratt - Kenosha WI, US Lisa A. Hasvold - Grayslake IL, US Dachun Liu - Vernon Hills IL, US Yujia Dai - Gurnee IL, US Steven D. Fidanze - Grayslake IL, US James H. Holms - Gurnee IL, US Robert A. Mantei - Franklin WI, US Keith F. McDaniel - Wauconda IL, US George S. Sheppard - Wilmette IL, US William J. McClellan - Waukegan IL, US
International Classification:
C07D 471/04 C07D 519/00
Abstract:
The present invention provides for compounds of formula (I)wherein R, R, R, R, and Rhave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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