Keith D Mcdaniel

US Patent:

6455571, Sep 24, 2002

Filed:

Oct 19, 1999

Appl. No.:

09/421787

Inventors:

Clarence J. Maring - Palatine IL
Yu Gui Gu - Grayslake IL
Hui-Ju Chen - Grayslake IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
William J. Flosi - Des Plaines IL
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Grayslake IL
Larry L. Klein - Lake Forest IL
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Keith F. McDaniel - Grayslake IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Noah P. Tu - Gurnee IL
Frank L. Wagenaar - Gurnee IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Paul E. Wiedeman - Deerfield IL
Yibo Xu - Ridgefield CT
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Malken Bayrakdarian - Verdun, CA
Xuehong Luo - Montreal, CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140

US Classification:

514423, 514422, 514397, 514365, 514374, 548532, 548533, 548518, 5483147, 548205, 548236, 548237

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

6831096, Dec 14, 2004

Filed:

Sep 24, 2002

Appl. No.:

10/253152

Inventors:

Clarence J. Maring - Palatine IL
Yu Gui Gu - Grayslake IL
Hui-Ju Chen - Grayslake IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
William J. Flosi - Des Plaines IL
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Boulder CO
Larry L. Klein - Lake Forest IL
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Keith F. McDaniel - Wauconda IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Noah P. Tu - Gurnee IL
Frank L. Wagenaar - Gurnee IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Paul E. Wiedeman - Deerfield IL
Yibo Xu - New Milford CT
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Malken Bayrakdarian - Verdun, CA
Xuehong Luo - Montreal, CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140

US Classification:

514423

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

7910595, Mar 22, 2011

Filed:

Dec 20, 2006

Appl. No.:

11/613810

Inventors:

David A. Betebenner - Libertyville IL, US
David A. DeGoey - Salem WI, US
Clarence J. Maring - Palatine IL, US
Allan C. Krueger - Gurnee IL, US
Nobuhiko Iwasaki - Buffalo Grove IL, US
Todd W. Rockway - Grayslake IL, US
Curt S. Cooper - Vernon Hills IL, US
David D. Anderson - Kenosha WI, US
Pamela L. Donner - Mundelein IL, US
Brian E. Green - Wonder Lake IL, US
Dale J. Kempf - Libertyville IL, US
Dachun Liu - Waukegan IL, US
Keith F. McDaniel - Wauconda IL, US
Darold L. Madigan - Elk Grove Village IL, US
Christopher E. Motter - Oak Creek WI, US
John K. Pratt - Kenosha WI, US
Jason P. Shanley - Chicago IL, US
Michael D. Tufano - Chicago IL, US
Rolf Wagner - Antioch IL, US
Rong Zhang - Niskayuna NY, US
Akhteruzzaman Molla - Gurnee IL, US
Hongmei Mo - Foster City CA, US
Sherie V L. Masse - Kenosha WI, US
Robert J. Carrick - Pleasant Prairie WI, US
Wenping He - Libertyville IL, US
Liangjun Lu - Kildeer IL, US
David J. Grampovnik - Waukegan IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 471/04
A01N 31/519
A61P 31/12

US Classification:

51426411, 544279, 5142641

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

US Patent:

7915411, Mar 29, 2011

Filed:

Dec 20, 2006

Appl. No.:

11/613825

Inventors:

David A. Betebenner - Libertyville IL, US
David A. DeGoey - Salem WI, US
Clarence J. Maring - Palatine IL, US
Allan C. Krueger - Gurnee IL, US
Nobuhiko Iwasaki - Buffalo Grove IL, US
Todd W. Rockway - Grayslake IL, US
Curt S. Cooper - Vernon Hills IL, US
David D. Anderson - Kenosha WI, US
Pamela L. Donner - Mundelein IL, US
Brian E. Green - Wonder Lake IL, US
Dale J. Kempf - Libertyville IL, US
Dachun Liu - Waukegan IL, US
Keith F. McDaniel - Wauconda IL, US
Darold L. Madigan - Elk Grove Village IL, US
Christopher E. Motter - Oak Creek WI, US
John K. Pratt - Kenosha WI, US
Jason P. Shanley - Chicago IL, US
Michael D. Tufano - Chicago IL, US
Rolf Wagner - Antioch IL, US
Rong Zhang - Niskayuna NY, US
Akhteruzzaman Molla - Gurnee IL, US
Hongmei Mo - Foster City CA, US
Sherie V L. Masse - Kenosha WI, US
Robert J. Carrick - Pleasant Prairie WI, US
Wenping He - Libertyville IL, US
Liangjun Lu - Kildeer IL, US
David J. Grampovnik - Waukegan IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 471/04
A61P 1/16

US Classification:

544279

Abstract:

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

US Patent:

8420596, Apr 16, 2013

Filed:

Sep 10, 2009

Appl. No.:

12/584716

Inventors:

Yiyin Ku - Buffalo Grove IL, US
Keith F. McDaniel - Wauconda IL, US
Hui-Ju Chen - Grayslake IL, US
Jason P. Shanley - Chicago IL, US
Dale J. Kempf - Libertyville IL, US
David J. Grampovnik - Waukegan IL, US

Assignee:

Abbott Laboratories - Abbott Park IL
Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 38/00

US Classification:

514 37

Abstract:

The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

US Patent:

8642538, Feb 4, 2014

Filed:

Apr 4, 2012

Appl. No.:

13/439551

Inventors:

Yiyin Ku - Buffalo Grove IL, US
Keith F. McDaniel - Wauconda IL, US
Hui-Ju Chen - Grayslake IL, US
Jason P. Shanley - Chicago IL, US
Dale J. Kempf - Libertyville IL, US
David J. Grampovnik - Waukegan IL, US

Assignee:

AbbVie, Inc. - North Chicago IL

International Classification:

A61K 38/00
A01N 37/18

US Classification:

514 43

Abstract:

The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

US Patent:

20130331382, Dec 12, 2013

Filed:

Mar 12, 2013

Appl. No.:

13/796437

Inventors:

Le WANG - Vernon Hills IL, US
Chang H. PARK - Wadsworth IL, US
Chaohong SUN - Gurnee IL, US
Keith F. McDANIEL - Wauconda IL, US
John K. PRATT - Kenosha WI, US
Todd N. SOLTWEDEL - Chicago IL, US
Michael D. WENDT - Vernon Hills IL, US
John H. HOLMS - Gurnee IL, US
Dachun LIU - Vernon Hills IL, US
George S. SHEPPARD - Wilmette IL, US

International Classification:

A61K 31/541
A61K 31/50
A61K 45/06
C07D 213/64
A61K 31/4412
A61K 31/5377
A61K 31/501
C07D 403/04
C07D 401/10
C07D 403/10
C07D 417/10
C07D 413/10
C07D 237/14
C07D 401/04

US Classification:

5142278, 544239, 514247, 546302, 514351, 544238, 51425203, 51425202, 51425205, 51425204, 51425206, 544114, 5142365, 544 60

Abstract:

The present invention provides for compounds of formula (I)wherein A, A, A, A, J, and Xhave any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula I.

US Patent:

20210070756, Mar 11, 2021

Filed:

Nov 16, 2020

Appl. No.:

17/099133

Inventors:

- North Chicago IL, US
Dachun Liu - Vernon Hills IL, US
Robert A. Mantei - Franklin WI, US
Keith F. McDaniel - Wauconda IL, US
John Pratt - Kenosha WI, US
George S. Sheppard - Wilmette IL, US
Le Wang - Vernon Hills IL, US
Andrew Bogdan - Evanston IL, US
James H. Holms - Gurnee IL, US
Justin D. Dietrich - Lindenhurst IL, US
Jasmina Marjanovic - Chicago IL, US
Lisa A. Hasvold - Grayslake IL, US
Yujia Dai - Gurnee IL, US

International Classification:

C07D 471/22
A61P 15/16
A61P 31/18
A61P 13/12
A61P 35/00
C07D 471/16

Abstract:

The present invention provides for compounds of formula (I)wherein R, R, R, Y, Y, Y, A, A, A, and Ahave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).