Keith D Myers

US Patent:

20130029915, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560757

Inventors:

W. Jerry Mezger - Coto de Caza CA, US
Keith E. Myers - Lake Forest CA, US

Assignee:

HARBOR MEDTECH, INC. - Irvine CA

International Classification:

A61K 38/39
A61P 43/00
A61P 1/02
A61P 17/02
A61P 15/02

US Classification:

514 172

Abstract:

Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.

US Patent:

20130030153, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560696

Inventors:

W. Jerry Mezger - Coto de Caza CA, US
Keith E. Myers - Lake Forest CA, US

Assignee:

HARBOR MEDTECH, INC. - Irvine CA

International Classification:

C07K 14/78

US Classification:

530356

Abstract:

Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.

US Patent:

20130030526, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560713

Inventors:

W. Jerry Mezger - Coto de Caza CA, US
Keith E. Myers - Lake Forest CA, US

Assignee:

HARBOR MEDTECH, INC. - Irvine CA

International Classification:

C07K 14/78
A61F 2/02
A61P 31/00
A61K 38/39
A61P 17/00

US Classification:

623 1111, 530356

Abstract:

Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.