Keith A. Webster - Palo Alto CA Nanette H. Bishopric - Palo Alto CA
Assignee:
SRI International - Menlo Park CA
International Classification:
C12N 1500 C07H 2104
US Classification:
4353201
Abstract:
Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e. g. , bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxic conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.
, so the team is remembered for its free-throw shooting. But we had terrific players, including Joe Carrabino, who became the programs career leading scorer; Bob Ferry, Danny Ferrys older brother; Arne Duncan, now the United States secretary of education; point guard Pat Smith; and a terrific shooter in Keith Webster, a freshman that year.