Kelly J Meyers

US Patent:

20090099062, Apr 16, 2009

Filed:

May 29, 2008

Appl. No.:

12/129250

Inventors:

Ethan Lee - Brentwood TN, US
Laura Lee - Brentwood TN, US
Curtis Thorne - Nashville TN, US
Emilios Tahinci - Nashville TN, US
Kelly Christian Meyers - Nashville TN, US

International Classification:

A61K 38/02
G01N 33/48
C12Q 1/66
C12N 5/06
A61K 31/337

US Classification:

514 2, 436 63, 435 8, 435375, 514449

Abstract:

The present invention concerns a pyrvinium compound or an analog thereof for the treatment of cancers. This compound inhibits Wnt activity in the cells of cancers such as adrenocortical, hepatocellular, hepatoblastoma, malignant melanoma, ovarian, Wilm's tumor, Barrett's esophageal, glioma, bladder, breast, gastric, head & neck, lung cell, mesothelioma, and cervical cancers. The present invention also provides a method for assaying for compounds that alter Wnt pathway activity. Also provided are methods for treating Wnt-related non-cancer disease states.