Kelly Forney Stevens

US Patent:

20210213171, Jul 15, 2021

Filed:

Mar 26, 2021

Appl. No.:

17/213423

Inventors:

- Cambridge MA, US
- Philadelphia PA, US
Ritika CHATURVEDI - Philadelphia PA, US
Michael T. YANG - West Windsor NJ, US
Kelly R. STEVENS - Seattle WA, US
Sangeeta N. BHATIA - Lexington MA, US

International Classification:

A61L 27/50
A61L 27/22
A61L 27/24
A61L 27/38
A61K 35/44
A61L 27/40
A61L 27/36

Abstract:

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

US Patent:

20200101201, Apr 2, 2020

Filed:

Oct 1, 2019

Appl. No.:

16/589768

Inventors:

- Philadelphia PA, US
- Cambridge MA, US
Ritika Chaturvedi - Philadelphia PA, US
Michael T. Yang - West Windsor NJ, US
Kelly Stevens - Seattle WA, US
Sangeeta Bhatia - Lexington MA, US

Assignee:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
The Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61L 27/50
A61K 35/44
A61L 27/40
A61L 27/22
A61L 27/24
A61L 27/38
A61L 27/36

Abstract:

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

US Patent:

20150082468, Mar 19, 2015

Filed:

Feb 28, 2013

Appl. No.:

14/381866

Inventors:

- Cambridge MA, US
Kelly R. Stevens - Cambridge MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

C12N 11/04
A61K 35/12
G01N 33/50
C12N 11/10
C12N 11/08

US Classification:

800 9, 435177, 435178, 435182, 435 29, 424 937

Abstract:

The invention features an “inverse patterning” or “Intaglio-Void/Embed-Relief Topographic (In VERT) molding” manufacturing process for generating high-resolution three-dimensional (3D) multi-cellular microstructures in distinct cellular compartments of a single hydrogel. The platform has general utility in the development of engineered tissues for human therapies, drug testing, and disease models. Additionally, the platform can serve as a model system for studying 3D cell-cell interactions in fields as diverse as stem cell biology to the development of cancer therapeutics.