Kelly A Swinney

US Patent:

6809828, Oct 26, 2004

Filed:

Jan 24, 2002

Appl. No.:

10/053877

Inventors:

Darryl J. Bornhop - Lubbock TX
Kelly Swinney - Martinsville VA
Dmitry Markov - Lubbock TX

Assignee:

Texas Tech University - Lubbock TX

International Classification:

G01B 902

US Classification:

356517

Abstract:

An on-chip interferometric backscatter detector (OCIBD) makes use of plastic substrates in which a rectangular sample channel is formed. While any plastic material can be used to form the channel substrate, the substrate is most preferably formed from polydimethylsiloxane (PDMS). An incident laser beam reflects off of the sample channel walls and through the sample in the channel, thereby generating backscattered reflections that create interference fringe patterns. The fringe patterns are detected by a photodetector and used to determine various properties of the sample. To provide the best results, the laser beam diameter should be no smaller than the channel width so that the entire channel will be illuminated by the beam, and preferably should be slightly, e. g. , 5%, larger. This will insure that the laser light reflected off of the walls of the channel will generate the desired interference fringe patterns, despite the less than optimum rectangular geometry of the channel walls.

US Patent:

7144502, Dec 5, 2006

Filed:

Jun 4, 2004

Appl. No.:

10/861176

Inventors:

Adam Fermier - Easton PA, US
Kelly Swinney - Bethlehem PA, US

Assignee:

Johnson & Johnson - New Brunswick NJ

International Classification:

B01D 15/08

US Classification:

2101982, 210656, 210659, 210101

Abstract:

In accordance with one aspect of the present invention, an ultra-high pressure chromatography system (UHPLC) is provided and includes a high pressure chromatography arrangement of equipment (HPLC system) as well as a UHPLC module for converting the HPLC system into the UHPLC system. One exemplary module includes a gradient storage column fluidly connected to the HPLC equipment in a post injector manner such that an injection plug can be selectively delivered and stored, in an inverted manner, therein at low pressures, while stored injection plug (gradient) is delivered to an analytical column using higher pressures for chromatographic separation.

US Patent:

20060093515, May 4, 2006

Filed:

Nov 3, 2004

Appl. No.:

10/980468

Inventors:

Adam Fermier - Easton PA, US
Kelly Swinney - Bethlehem PA, US
Benjamin Young - Sheffield PA, US

International Classification:

C12Q 1/68

US Classification:

422050000

Abstract:

The present invention relates to an automated solution generator, such as for use in generating buffering or clinical formulations or mobile phase solutions for chromatography systems, and methods for operating the automated solution generator to accurately dispense solutions, perform dilutions and prepare solutions with reduced user intervention.

US Patent:

20070185619, Aug 9, 2007

Filed:

Sep 2, 2004

Appl. No.:

10/932450

Inventors:

Adam Fermier - Easton PA, US
Kelly Swinney - Bethlehem PA, US
Benjamin Young - Sheffield PA, US

International Classification:

G05B 21/00

US Classification:

700265000, 700282000, 700305000

Abstract:

The present invention relates to an automated solution generator, such as for use in generating buffering or clinical formulations or mobile phase solutions for chromatography systems, and methods for operating the automated solution generator to accurately dispense solutions, perform dilutions and prepare solutions with reduced user intervention.

US Patent:

6381025, Apr 30, 2002

Filed:

Mar 6, 2000

Appl. No.:

09/519860

Inventors:

Darryl J. Bornhop - Lubbock TX
Kelly Swinney - Martinsville VA
Dmitry Markov - Lubbock TX

Assignee:

Texas Tech University - Lubbock TX

International Classification:

G01N 2141

US Classification:

356517, 356134

Abstract:

An optical detection scheme for on-chip, high sensitivity refractive index detection is based on micro-interferometry, and allows for picoliter detection volumes and universal analyte sensitivity. The invention employs three main elements: a source of coherent light, such as a VCSEL, laser diode or HeâNe laser; an etched channel of capillary dimensions in a substrate for reception of a sample to be analyzed; and a photodetector for detecting laser light reflected off of the channel. The laser source generates an unfocused laser beam that is incident on the etched channel. A unique multi-pass optical configuration is inherently created by the channel characteristics, and is based on the interaction of the unfocused laser beam and the curved surface of the channel, that allows RI measurements in small volumes at high sensitivity. The entire device, including the laser and the photodetector can be formed on a single microchip. The detector has numerous applications, including universal/RI detection for CE (capillary electrophoresis), CEC (capillary electrochromatography) and FIA, physiometry, cell sorting/detection by scatter, ultra micro calorimetry, flow rate sensing and temperature sensing.

US Patent:

20160354316, Dec 8, 2016

Filed:

Oct 31, 2014

Appl. No.:

15/035969

Inventors:

Kelly Ann SWINNEY - Boston MA, US
Patricia Nell HURTER - Harvard MA, US
David E. NADIG - Dorchester MA, US
David SMITH - Newton MA, US
Vance Hayden THOMAS - Duxbury MA, US
Martin Paul WARMAN - Hingham MA, US
- Boston MA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Boston MA

International Classification:

A61K 9/20
A61K 31/47
A61K 31/443

Abstract:

Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.