Ken K Rice

US Patent:

7994172, Aug 9, 2011

Filed:

Dec 27, 2005

Appl. No.:

11/722291

Inventors:

Ken Rice - San Rafael CA, US
Erick Wang Co - San Diego CA, US
Moon Hwan Kim - Palo Alto CA, US
Lynn Canne Bannen - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Donna Tra Le - San Jose CA, US
Amy Lew Tsuhako - Milpitas CA, US
John Nuss - Danville CA, US
Yong Wang - Foster City CA, US
Wei Xu - Danville CA, US
Rhett Ronald Klein - Chicago IL, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C07D 487/04
A61K 31/519
A61P 35/00

US Classification:

51425216, 5142621, 544262

Abstract:

The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

US Patent:

62112287, Apr 3, 2001

Filed:

Mar 29, 1999

Appl. No.:

9/280227

Inventors:

Ken Duane Rice - Palo Alto CA
Jeffrey Mark Dener - Daly City CA
Anthony Robert Gangloff - San Mateo CA
Elaine Yee-Lin Kuo - San Francisco CA

Assignee:

Axys Pharmaceuticals, Inc - South San Francisco CA

International Classification:

A61K 71335
C07C32112

US Classification:

514450

Abstract:

Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

US Patent:

56566603, Aug 12, 1997

Filed:

May 31, 1995

Appl. No.:

8/455286

Inventors:

Robert T. Lum - Palo Alto CA
Heinz W. Gschwend - Belmont CA
Barr E. Bauer - Foster City CA
Elaine Kuo - San Francisco CA
Ken Rice - Redwood City CA

Assignee:

Arris Pharmaceutical Corporation - South San Francisco CA

International Classification:

A61K 31335
A61K 3127
C07C27106
C07C23720

US Classification:

514467

Abstract:

The present invention describes compounds, methods and compositions effective to treat mast cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The compounds of the invention comprise novel mono- and di-aminomethylbenzyl, aminobenzyl, guanidylbenzyl and benzyl tryptase inhibitors. The compositions for treating mast cell mediated inflammatory conditions include oral, inhalant and topical preparations as well as devices comprising such preparations.

US Patent:

60229691, Feb 8, 2000

Filed:

Sep 14, 1995

Appl. No.:

8/522157

Inventors:

Ken Duane Rice - Palo Alto CA
Jeffrey Mark Dener - Daly City CA
Anthony Robert Gangloff - San Mateo CA
Elaine Yee-Lin Kuo - San Francisco CA

Assignee:

AXYS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07D29532
C07D295205

US Classification:

544357

Abstract:

Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.