Kenneth R Carson

US Patent:

6951848, Oct 4, 2005

Filed:

Mar 12, 2002

Appl. No.:

10/096361

Inventors:

Geraldine C. B. Harriman - Charlestown RI, US
Kenneth G. Carson - Needham MA, US
Daniel L. Flynn - Natick MA, US
Michael E. Solomon - New York NY, US
Yuntao Song - Ann Harbor MI, US
Bharat K. Trivedi - Farmington Hills MI, US
Bruce D. Roth - Plymouth MI, US
Christine N. Kolz - Dexter MI, US
Ly Pham - Ann Harbor MI, US

Assignee:

Millennium Pharmaceuticals, Inc., - Cambridge MA

International Classification:

A61K031/33
A61K031/40
A61K031/405
C07D209/04

US Classification:

514183, 514408, 514412, 514415, 514424, 548469, 548485, 548511, 548452

Abstract:

Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.

US Patent:

20050075348, Apr 7, 2005

Filed:

Nov 8, 2004

Appl. No.:

10/983929

Inventors:

Geraldine Harriman - Charlestown RI, US
Kenneth Carson - Needham MA, US
Daniel Flynn - Natick MA, US
Michael Solomon - New York NY, US
Yuntao Song - Ann Harbor MI, US
Bharat Trivedi - Farmington Hills MI, US
Bruce Roth - Plymouth MI, US
Christine Kolz - Dexter MI, US
Ly Pham - Ann Harbor MI, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K031/519
A61K031/53
A61K031/52

US Classification:

514260100, 514263200, 544255000, 544277000, 514242000, 544184000

Abstract:

Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.