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Said M. Sebti - Tampa FL Andrew D. Hamilton - Guilford CT David J. Augeri - Kenosha WI Kenneth J. Barr - Chicago IL Stephen A. Fakhoury - Mundelein IL David A. Janowick - Beach Park IL Douglas M. Kalvin - Buffalo Grove IL Stephen J. O'Connor - Wilmette IL Saul H. Rosenberg - Grayslake IL Wang Shen - Gurnee IL Rolf E. Swenson - Grayslake IL Bryan K. Sorensen - Waukegan IL Gerard M. Sullivan - Round Lake Beach IL Andrew S. Tasker - Simi Valley CA James T. Wasicak - Waterford WI Lissa T. J. Nelson - Highland Park IL Kenneth J. Henry - Fishers IN Le Wang - Mundelein IL Gang Liu - Gurnee IL Indrani W. Gunawardana - Libertyville IL
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
C07C26302 C07C30300 A61K 3138
US Classification:
514570
Abstract:
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R. sub. 1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L. sub. 2 --, and (i) heterocyclic-L. sub. 2 --; R. sub. 2 is selected from ##STR2## (b) --C(O)NH--CH(R. sub. 14)--C(O)OR. sub. 15, ##STR3## (d) --C(O)NH--CH(R. sub. 14)--C(O)NHSO. sub. 2 R. sub. 16, (e) --C(O)NH--CH(R. sub. 14)-tetrazolyl, (f) --C(O)NH-heterocyclic, and (g) --C(O)NH--CH(R. sub. 14)--C(O)NR. sub. 17 R. sub. 18 ; R. sub. 3 is heterocyclic, aryl, substituted or unsubstituted cycloalkyl; R. sub. 4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L. sub. 1 is absent or is selected from (a) --L. sub. 4 --N(R. sub. 5)--L. sub. 5 --, (b) --L. sub. 4 --O--L. sub.
Said M. Sebti - Tampa FL Andrew D. Hamilton - Guilford CT Kenneth J. Barr - Chicago IL Stephen A. Fakhoury - Mundelein IL Stephen J. O'Connor - Wilmette IL Saul H. Rosenberg - Grayslake IL Wang Shen - Gurnee IL Bryan K. Sorensen - Waukegan IL Gerard M. Sullivan - Round Lake Beach IL James T. Wasicak - Waterford IL Kenneth J. Henry - Fishers IN Le Wang - Mundelein IL
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R. sub. 1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L. sub. 2 --, and (i) heterocyclic-L. sub. 2 --; R. sub. 2 is selected from (a) ##STR2## (b) --C(O)NH--CH(R. sub. 14)--C(O)OR. sub. 15, ##STR3## (d) --C(O)NH--CH(R. sub. 14)--C(O)NHSO. sub. 2 R. sub. 16, (e) --C(O)NH--CH(R. sub. 14)-tetrazolyl, (f) --C(O)NH-heterocyclic, and (g) --C(O)NH--CH(R. sub. 14)--C(O)NR. sub. 17 R. sub. 18 ; R. sub. 3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, ##STR4## and --P(W)R. sup. R3 R. sup. R3 '; R. sub. 4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L. sub. 1 is absent or is selected from (a) --L. sub. 4 --N(R. sub. 5)--L. sub.
Said M. Sebti - Tampa FL Andrew D. Hamilton - Guilford CT David J. Augeri - Kenosha WI Kenneth J. Barr - Chicago IL Stephen A. Fakhoury - Mundelein IL David A. Janowick - Beach Park IL Douglas M. Kalvin - Buffalo Grove IL Stephen J. O'Connor - Wilmette IL Saul H. Rosenberg - Grayslake IL Wang Shen - Gurnee IL Rolf E. Swenson - Grayslake IL Bryan K. Sorenson - Waukegan IL Gerard M. Sullivan - Round Lake Beach IL Andrew S. Tasker - Simi Valley CA James T. Wasicak - Waterford WI Lissa T. J. Nelson - Highland Park IL Kenneth J. Henry - Fishers IN Le Wang - Mundelein IL
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 31192 C07C 53134
US Classification:
514539
Abstract:
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R. sub. 1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L. sub. 2 --, and (i) heterocyclic-L. sub. 2 --; R. sub. 2 is selected from (a) ##STR2## (b) --C(O)NH--CH(R. sub. 14)--C(O)OR. sub. 15, ##STR3## (d) --C(O)NH--CH(R. sub. 14)--C(O)NHSO. sub. 2 R. sub. 16, (e) --C(O)NH--CH(R. sub. 14)-tetrazolyl, (f) --C(O)NH-heterocyclic, and (g) --C(O)NH--CH(R. sub. 14)--C(O)NR. sub. 17 R. sub. 18 ; R. sub. 3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, ##STR4## and --P(W)R. sup. R3 R. sup. R3' ; R. sub. 4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L. sub. 1 is absent or is selected from (a) --L. sub. 4 --N(R. sub. 5)--L. sub.
Name / Title
Company / Classification
Phones & Addresses
Kenneth R. Henry
GREAT LAKES INNOVATIVE MARINE SYSTEMS, LTD
Kenneth M Henry
K & T VENTURES, LTD
Kenneth R Henry
GREAT LAKE INNOVATIVE MARINE SYSTEMS, LTD
Kenneth L. Henry President, Senior VP, Vice President, Executive Vice Presi
Earle M. Jorgensen Company Whol Steel & Aluminum Products · Metals Service Center Mfg Sheet Metalwork Mfg Fabricated Plate Wrk · Metals Service Center
Past: Owner at caninecitysurvival I'm a 30+ year canine specialist. My teaching method is holistic as I mimic the practices is mother dog with their young to obtain our results.
My present dog... I'm a 30+ year canine specialist. My teaching method is holistic as I mimic the practices is mother dog with their young to obtain our results.
My present dog Coral Reef III is doing upward of 380 commands & tasks in two languages. He played Limbo the Dog in a movie with celebrated actor "Ben...