Kenneth W Jacobs

US Patent:

60840714, Jul 4, 2000

Filed:

Jun 9, 1998

Appl. No.:

9/094287

Inventors:

Lisa A. Racie - Acton MA
Kenneth Jacobs - Newton MA
Zhijian Lu - Bedford MA
Edward R. LaVallie - Harvard MA
John M. McCoy - Reading MA

Assignee:

Genetics Institute - Cambridge MA

International Classification:

C07K 1452
A61K 3819
C12N 1519

US Classification:

530351

Abstract:

A chemokine, human L105, is disclosed.

US Patent:

48186805, Apr 4, 1989

Filed:

Dec 18, 1985

Appl. No.:

6/811034

Inventors:

Mary Collins - Natick MA
Joseph P. Dougherty - Somerville MA
Marian S. Ellwood - Lebanon NJ
Edward F. Fritsch - Concord MA
Kenneth A. Jacobs - Newton MA

International Classification:

C12Q 168
C12N 3353
G01N 33566

US Classification:

435 6

Abstract:

A diagnostic reagent is disclosed which is capable of binding to a target nucleotide sequence which is bound to a labeled polynucleotide in a target binding region which is at least partially co-extensive with the target binding region in the probe polynucleotide which is capable of binding to the target nucleotide sequence. A method is disclosed in which the reagent is contacted with a sample and with a capturing polynucleotide under conditions such that target nucleotide which may be present in the sample binds to the probe polynucleotide and displaces labeled polynucleotide from the reagent complex, and the capturing polynucleotide binds selectively to the displaced labeled polynucleotide in the region of the labeled polynucleotide that had been bound to the probe polynucleotide. Determination of the displaced nucleotide gives a value which is a function of the presence and concentration of target nucleotide in the sample.